Ignet

Gene Information

Gene symbol: PGF

Gene name: placental growth factor

HGNC ID: 8893

Synonyms: PLGF, PlGF-2, PlGF, SHGC-10760, D12S1900

Related Genes

#	Gene Symbol	Number of hits
1	IFNG	1 hits
2	MMP1	1 hits
3	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	25924700	To test the hypothesis that MMP expression in luteal cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells.
2	25924700	To test the hypothesis that MMP expression in luteal cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells.
3	25924700	Luteal cells obtained from the CL at the mid-luteal stage (days 8-12 after ovulation) were cultured with PGF (0.01, 0.1, 1 μM), IFNG (0.05, 0.5, 5 nM) and TNF (0.05, 0.5, 0.5 nM) alone or in combination for 24 h.
4	25924700	Luteal cells obtained from the CL at the mid-luteal stage (days 8-12 after ovulation) were cultured with PGF (0.01, 0.1, 1 μM), IFNG (0.05, 0.5, 5 nM) and TNF (0.05, 0.5, 0.5 nM) alone or in combination for 24 h.
5	25924700	PGF and IFNG significantly increased the expression of MMP-1 mRNA.
6	25924700	PGF and IFNG significantly increased the expression of MMP-1 mRNA.
7	25924700	In addition, 1 μM PGF in combination with 5 nM IFNG stimulated MMP-1 and MMP-9 mRNA expression significantly more than either treatment alone.
8	25924700	In addition, 1 μM PGF in combination with 5 nM IFNG stimulated MMP-1 and MMP-9 mRNA expression significantly more than either treatment alone.
9	25924700	In contrast, IFNG significantly decreased the level of MMP-14 mRNA.
10	25924700	In contrast, IFNG significantly decreased the level of MMP-14 mRNA.
11	25924700	The mRNA expression of TIMP-1, which preferentially inhibits MMP-1, was suppressed by 5 nM INFG.
12	25924700	The mRNA expression of TIMP-1, which preferentially inhibits MMP-1, was suppressed by 5 nM INFG.
13	25924700	One μM PGF and 5 nM IFNG suppressed TIMP-2 mRNA expression.
14	25924700	One μM PGF and 5 nM IFNG suppressed TIMP-2 mRNA expression.
15	25924700	These results suggest a new role of MMPs: luteal MMPs stimulated by PGF and IFNG break down the extracellular matrix surrounding luteal cells, which accelerates detachment from the CL during luteolysis, providing an essential prerequisite for outflow of luteal cells from the CL to lymphatic vessels.
16	25924700	These results suggest a new role of MMPs: luteal MMPs stimulated by PGF and IFNG break down the extracellular matrix surrounding luteal cells, which accelerates detachment from the CL during luteolysis, providing an essential prerequisite for outflow of luteal cells from the CL to lymphatic vessels.
17	22186103	In this study, the presence of cytokines tumor necrosis factor alpha (TNF) and interferon gamma (IFNG), and their receptors (TNFRI, TNFRII and IFNRI), was investigated in equine CL throughout the luteal phase.
18	22186103	In this study, the presence of cytokines tumor necrosis factor alpha (TNF) and interferon gamma (IFNG), and their receptors (TNFRI, TNFRII and IFNRI), was investigated in equine CL throughout the luteal phase.
19	22186103	The effects of TNF and IFNG on secretory function and viability of luteal cells were defined in vitro.
20	22186103	The effects of TNF and IFNG on secretory function and viability of luteal cells were defined in vitro.
21	22186103	In the mid luteal phase, TNF increased PGF(2α) secretion and TNF+IFNG decreased PGE(2) secretion.
22	22186103	In the mid luteal phase, TNF increased PGF(2α) secretion and TNF+IFNG decreased PGE(2) secretion.
23	22186103	In the regressing luteal phase, TNF, IFNG and TNF+IFNG decreased P(4) and PGE(2) secretion, but TNF and TNF+IFNG increased PGF(2α) secretion by luteal cells.
24	22186103	In the regressing luteal phase, TNF, IFNG and TNF+IFNG decreased P(4) and PGE(2) secretion, but TNF and TNF+IFNG increased PGF(2α) secretion by luteal cells.
25	22186103	Cell viability was reduced by TNF+IFNG in regressing CL.
26	22186103	Cell viability was reduced by TNF+IFNG in regressing CL.
27	22186103	These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine CL and indicate their potential involvement in regulation of luteal function.
28	22186103	These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine CL and indicate their potential involvement in regulation of luteal function.