Ignet

Gene Information

Gene symbol: PHLPP

Gene name: PH domain and leucine rich repeat protein phosphatase

HGNC ID: 20610

Related Genes

#	Gene Symbol	Number of hits
1	MAPK3	1 hits
2	STAT1	1 hits

Related Sentences

#	PMID	Sentence
1	24443556	A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
2	24443556	Mechanistic analysis revealed that PHLPP1 suppressed LPS/IFN-γ-induced phosphorylation of ser⁷²⁷ STAT1; however, the underlying mechanisms differed.
3	24443556	PHLPP1 reduced IFN-γ-stimulated but not LPS-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-γ-induced ser⁷²⁷ STAT1 phosphorylation and iNOS expression.
4	24443556	Blockade of p38 abolished LPS-stimulated phosphorylation of ser⁷²⁷ STAT1 and iNOS expression.
5	24443556	Furthermore, PHLPP1 suppressed LPS-induced phosphorylation of tyr⁷⁰¹ STAT1 by dampening p38-dependent IFN-β feedback.
6	24443556	A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
7	24443556	Mechanistic analysis revealed that PHLPP1 suppressed LPS/IFN-γ-induced phosphorylation of ser⁷²⁷ STAT1; however, the underlying mechanisms differed.
8	24443556	PHLPP1 reduced IFN-γ-stimulated but not LPS-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-γ-induced ser⁷²⁷ STAT1 phosphorylation and iNOS expression.
9	24443556	Blockade of p38 abolished LPS-stimulated phosphorylation of ser⁷²⁷ STAT1 and iNOS expression.
10	24443556	Furthermore, PHLPP1 suppressed LPS-induced phosphorylation of tyr⁷⁰¹ STAT1 by dampening p38-dependent IFN-β feedback.
11	24443556	A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
12	24443556	Mechanistic analysis revealed that PHLPP1 suppressed LPS/IFN-γ-induced phosphorylation of ser⁷²⁷ STAT1; however, the underlying mechanisms differed.
13	24443556	PHLPP1 reduced IFN-γ-stimulated but not LPS-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-γ-induced ser⁷²⁷ STAT1 phosphorylation and iNOS expression.
14	24443556	Blockade of p38 abolished LPS-stimulated phosphorylation of ser⁷²⁷ STAT1 and iNOS expression.
15	24443556	Furthermore, PHLPP1 suppressed LPS-induced phosphorylation of tyr⁷⁰¹ STAT1 by dampening p38-dependent IFN-β feedback.
16	24443556	A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
17	24443556	Mechanistic analysis revealed that PHLPP1 suppressed LPS/IFN-γ-induced phosphorylation of ser⁷²⁷ STAT1; however, the underlying mechanisms differed.
18	24443556	PHLPP1 reduced IFN-γ-stimulated but not LPS-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-γ-induced ser⁷²⁷ STAT1 phosphorylation and iNOS expression.
19	24443556	Blockade of p38 abolished LPS-stimulated phosphorylation of ser⁷²⁷ STAT1 and iNOS expression.
20	24443556	Furthermore, PHLPP1 suppressed LPS-induced phosphorylation of tyr⁷⁰¹ STAT1 by dampening p38-dependent IFN-β feedback.