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Gene Information
Gene symbol: PIK3R1
Gene name: phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
HGNC ID: 8979
Synonyms: GRB1, p85-ALPHA, p85
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | LAT | 1 hits |
| 2 | PIK3CG | 1 hits |
| 3 | PTK2B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25387834 | Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells. |
| 2 | 25387834 | We have previously shown that Pyk2 is activated downstream of the TCR in a PI3K-independent manner. |
| 3 | 25387834 | We observed that Pyk2 localized with the p85 regulatory subunit of PI3K at the LAT complex and that PI3K-dependent signaling was impaired in Pyk2-deficient T cells. |
| 4 | 25387834 | Likewise, functions downstream of PI3K, including IFN-γ production and proliferation, were also suppressed in human T cells deficient in Pyk2. |
| 5 | 25387834 | Collectively, these data demonstrate that Pyk2 is a critical regulator of PI3K function downstream of the TCR. |