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Gene Information
Gene symbol: PLCB1
Gene name: phospholipase C, beta 1 (phosphoinositide-specific)
HGNC ID: 15917
Synonyms: KIAA0581, PLC-I, PLC154
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PIK3CA | 1 hits |
| 2 | PLCG1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25960930 | We found that IL-15 improves NK cell viability, granzyme B expression, degranulation capacity and interferon-γ (IFNγ) secretion independently of PKC-θ. |
| 2 | 25960930 | Furthermore, IFNα induces PKC-θ auto-phosphorylation in NK cells, in a signal transduction pathway involving both phosphatidylinositol-3-kinase (PI3K) and phospholipase-C (PLC) activation. |
| 3 | 25960930 | PKC-θ dependence was further implicated in IFNα-induced transcriptional upregulation of chemokine (C-X-C motif) ligand 10 (CXCL10), a signal transducer and activator of transcription-1 (STAT-1)-dependent target of IFNα. |
| 4 | 25960930 | The absence of PKC-θ did not affect IFNα-induced STAT-1 Tyr701 phosphorylation but affected the increase in STAT-1 phosphorylation on Ser727, attenuating CXCL10 secretion. |