- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: PLCG1
Gene name: phospholipase C, gamma 1
HGNC ID: 9065
Synonyms: PLC148, PLC-II, PLCgamma1, NCKAP3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT3 | 1 hits |
| 2 | CBLB | 1 hits |
| 3 | CX3CR1 | 1 hits |
| 4 | DLG1 | 1 hits |
| 5 | FKBP1A | 1 hits |
| 6 | IL12A | 1 hits |
| 7 | IL2RA | 1 hits |
| 8 | IL7R | 1 hits |
| 9 | ITK | 1 hits |
| 10 | JUN | 1 hits |
| 11 | MALT1 | 1 hits |
| 12 | NCAM1 | 1 hits |
| 13 | NFATC2 | 1 hits |
| 14 | NOG | 1 hits |
| 15 | PIK3CA | 1 hits |
| 16 | PLCB1 | 1 hits |
| 17 | RBM12B | 1 hits |
| 18 | SPRED1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25122922 | PL-C also synergized with IL-12, even at the low cytokine concentration of 0.1 ng/ml, and stimulated IFN-γ production in both human CD56(bright) and CD56(dim) NK cell subsets. |
| 2 | 25122922 | PL-C also synergized with IL-12, even at the low cytokine concentration of 0.1 ng/ml, and stimulated IFN-γ production in both human CD56(bright) and CD56(dim) NK cell subsets. |
| 3 | 25122922 | However, IL-12 and IL-15Rs and their related STAT signaling pathways were not responsible for the enhanced IFN-γ secretion by PL-C. |
| 4 | 25122922 | However, IL-12 and IL-15Rs and their related STAT signaling pathways were not responsible for the enhanced IFN-γ secretion by PL-C. |
| 5 | 25960930 | We found that IL-15 improves NK cell viability, granzyme B expression, degranulation capacity and interferon-γ (IFNγ) secretion independently of PKC-θ. |
| 6 | 25960930 | Furthermore, IFNα induces PKC-θ auto-phosphorylation in NK cells, in a signal transduction pathway involving both phosphatidylinositol-3-kinase (PI3K) and phospholipase-C (PLC) activation. |
| 7 | 25960930 | PKC-θ dependence was further implicated in IFNα-induced transcriptional upregulation of chemokine (C-X-C motif) ligand 10 (CXCL10), a signal transducer and activator of transcription-1 (STAT-1)-dependent target of IFNα. |
| 8 | 25960930 | The absence of PKC-θ did not affect IFNα-induced STAT-1 Tyr701 phosphorylation but affected the increase in STAT-1 phosphorylation on Ser727, attenuating CXCL10 secretion. |
| 9 | 22984568 | Additional validation strategies included significant association of single nucleotide polymorphisms (SNPs) in signature genes with sarcoidosis susceptibility and severity (unbiased signature genes - CX3CR1, FKBP1A, NOG, RBM12B, SENS3, TSHZ2; T cell/JAK-STAT pathway genes such as AKT3, CBLB, DLG1, IFNG, IL2RA, IL7R, ITK, JUN, MALT1, NFATC2, PLCG1, SPRED1). |