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Gene Information
Gene symbol: PLVAP
Gene name: plasmalemma vesicle associated protein
HGNC ID: 13635
Synonyms: gp68, PV-1, PV1, FELS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD28 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | IFNG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28248972 | Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production. |
| 2 | 28248972 | A decrease in the activation profile of both T CD4+ and T CD8+ eye-infiltrating lymphocytes was evidenced. |
| 3 | 28248972 | In the periphery, T CD4+ cells from PV1-treated mice also showed a decrease in their activation status, with reduced expression of CD69, CD25, and PD-1 molecules. |
| 4 | 28248972 | In addition, frequency of CD4+IFN-γ+ T cells was significantly lower in PV1-treated group, but not of IL-17-producing T cells. |
| 5 | 28248972 | Moreover, after specific restimulation, PV1 blockade selectively blocked IFN-γ production by CD4+ lymphocytes Taken together, our data suggest that mPEG PV1-Fab' acts mainly on IFN-γ-producing CD4+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye. |