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Gene Information
Gene symbol: PMAIP1
Gene name: phorbol-12-myristate-13-acetate-induced protein 1
HGNC ID: 9108
Synonyms: APR, NOXA
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
24901046
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Apolipoprotein L1 and apolipoprotein L6 have been recently described as novel pro-death BH3-only proteins that are also capable of regulating autophagy.
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2 |
24901046
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In an in-silico screening to discover novel putative BH3-only proteins, we identified yet another member of the apolipoprotein L family, apolipoprotein L2 (ApoL2), as a BH3 motif-containing protein.
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3 |
24901046
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ApoL2 has been suggested to behave as a BH3-only protein and mediate cell death induced by interferon-gamma or viral infection.
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4 |
24901046
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As previously described, we observed that ApoL2 protein was induced by interferon-gamma.
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5 |
24901046
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ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa.
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6 |
24901046
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We could, however, detect a weak interaction between ApoL2 and Bcl-2 by immunoprecipitation of the former, suggesting a role of ApoL2 in a Bcl-2-regulated process like autophagy.
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7 |
24901046
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However, in contrast to what has been described about its homologs ApoL1 and ApoL6, ApoL2 did not regulate autophagy.
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