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Gene Information

Gene symbol: PMAIP1

Gene name: phorbol-12-myristate-13-acetate-induced protein 1

HGNC ID: 9108

Synonyms: APR, NOXA

Related Genes

# Gene Symbol Number of hits
1 APOL2 1 hits
2 BMF 1 hits

Related Sentences

# PMID Sentence
1 24901046 Apolipoprotein L1 and apolipoprotein L6 have been recently described as novel pro-death BH3-only proteins that are also capable of regulating autophagy.
2 24901046 In an in-silico screening to discover novel putative BH3-only proteins, we identified yet another member of the apolipoprotein L family, apolipoprotein L2 (ApoL2), as a BH3 motif-containing protein.
3 24901046 ApoL2 has been suggested to behave as a BH3-only protein and mediate cell death induced by interferon-gamma or viral infection.
4 24901046 As previously described, we observed that ApoL2 protein was induced by interferon-gamma.
5 24901046 ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa.
6 24901046 We could, however, detect a weak interaction between ApoL2 and Bcl-2 by immunoprecipitation of the former, suggesting a role of ApoL2 in a Bcl-2-regulated process like autophagy.
7 24901046 However, in contrast to what has been described about its homologs ApoL1 and ApoL6, ApoL2 did not regulate autophagy.