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Gene Information

Gene symbol: PPARA

Gene name: peroxisome proliferator-activated receptor alpha

HGNC ID: 9232

Synonyms: hPPAR, NR1C1

Related Genes

#	Gene Symbol	Number of hits
1	CCL2	1 hits
2	CXCL10	1 hits

Related Sentences

#	PMID	Sentence
1	22378921	β (CCL2) and α (CXCL10) chemokine modulations by cytokines and peroxisome proliferator-activated receptor-α agonists in Graves' ophthalmopathy.
2	22378921	No data are present in the literature about the effect of cytokines on the prototype β chemokine (C-C motif) ligand 2 (CCL2) or of peroxisome proliferator-activated receptor α (PPARα (PPARA)) activation on CCL2 and CXCL10 chemokines secretion in fibroblasts or preadipocytes in Graves' ophthalmopathy (GO).
3	22378921	We have tested the effect of interferon γ (IFNγ (IFNG)) and tumor necrosis factor α (TNFα) on CCL2, and for comparison on the prototype α chemokine (C-X-C motif) ligand 10 (CXCL10), and the possible modulatory role of PPARα activation on secretion of these chemokines in normal and GO fibroblasts or preadipocytes in primary cell cultures.
4	22378921	PPARα activators were able to inhibit the secretion of CXCL10 and CCL2, while PPARγ activators were confirmed to be able to inhibit CXCL10 but had no effect on CCL2.
5	22378921	In conclusion, CCL2 and CXCL10 are modulated by IFNγ and TNFα in GO.
6	22378921	PPARα activators inhibit the secretion of the main prototype α (CXCL10) and β (CCL2) chemokines in GO fibroblasts or preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO.