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Gene Information

Gene symbol: PRKCA

Gene name: protein kinase C, alpha

HGNC ID: 9393

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	FOS	1 hits
3	HLA-C	1 hits
4	IFNG	1 hits
5	IL12A	1 hits
6	MAPK1	1 hits
7	NFKB1	1 hits
8	NR2F6	1 hits
9	TP53	1 hits

Related Sentences

#	PMID	Sentence
1	27723836	This attenuation of ROS is regulated in a manner which is dependent on Toll like Receptor (TLR) and also on the route of calcium influx, Protein Kinase C (PKC) and by Mitogen Activation Protein Kinase (MAPK) pathways.
2	24919548	Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.
3	24919548	In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered.
4	24919548	Mechanistically, only sustained high affinity antigen receptor-induced protein kinase C (PKC)-mediated phosphorylation has been shown to inactivate NR2F6, thereby displacing pre-bound NR2F6 from the DNA and, subsequently, allowing for robust NFAT/AP-1- and RORγt-mediated cytokine transcription.
5	23071669	These included five that were common to both ages (TNF, HNF4A, IL15, Progesterone, and YWHAZ), and others that were unique to 2 weeks (e.g.
6	23071669	MYC/MYCN, TGFB1, and IL2) and to 4 weeks (e.g.
7	23071669	IFNG, beta-estradiol, p53, NFKB, AKT, PRKCA, IL12, and HLA-C).
8	23071669	Based on the literature, genes that may play a role in regulating metabolic pathways at 2 weeks include Myc and HNF4A, and at 4 weeks, beta-estradiol, p53, Akt, HNF4A and AR.