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Gene Information
Gene symbol: RHEB
Gene name: Ras homolog enriched in brain
HGNC ID: 10011
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CRTC1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28424242 | mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. |
| 2 | 28424242 | CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. |
| 3 | 28424242 | We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. |
| 4 | 28424242 | By analyzing activated murine wild-type and Rheb-deficient CD4+ T cells, as well as murine CD4+ T cells activated in the presence of rapamycin, a pharmacologic inhibitor of mTORC1, we were able to identify six T-bet phosphorylation sites. |
| 5 | 28424242 | Five of these are novel, and four sites are consistently dephosphorylated in both Rheb-deficient CD4+ T cells and T cells treated with rapamycin, suggesting mTORC1 signaling controls their phosphorylation. |
| 6 | 28424242 | The reduced activity of the triple mutant T-bet is associated with its failure to recruit chromatin remodeling complexes to the Ifng gene promoter. |
| 7 | 28424242 | These results establish a novel mechanism by which mTORC1 regulates Th1 differentiation, through control of T-bet phosphorylation. |