Ignet

Gene Information

Gene symbol: RPS27A

Gene name: ribosomal protein S27a

HGNC ID: 10417

Synonyms: UBCEP80, Uba80, S27A

Related Genes

#	Gene Symbol	Number of hits
1	CRYAB	1 hits
2	CXCL10	1 hits
3	CXCL9	1 hits
4	GBP1	1 hits
5	IFNG	1 hits
6	MAP1LC3A	1 hits
7	PRKAR1A	1 hits
8	SQSTM1	1 hits
9	TNF	1 hits
10	TNFAIP3	1 hits
11	UBD	1 hits

Related Sentences

#	PMID	Sentence
1	27965446	C. muridarum, but not C. trachomatis, inclusions attract several markers of cell-autonomous immunity, including the ubiquitin-binding protein p62, the ubiquitin-like protein LC3, and guanylate-binding protein 1.
2	26043155	TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.
3	26043155	TNFAIP3/A20 is a ubiquitin-editing enzyme that is thought to be a negative regulator of autophagy in cell lines.
4	26043155	To determine whether TNFAIP3 regulates autophagy in CD4 T cells, we first analyzed Tnfaip3-deficient naïve CD4 T cells in vitro.
5	26043155	We demonstrated that Tnfaip3-deficient CD4 T cells exhibited reduced MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) puncta formation, increased mitochondrial content, and exaggerated reactive oxygen species (ROS) production.
6	26043155	These results indicate that TNFAIP3 promotes autophagy after T cell receptor (TCR) stimulation in CD4 T cells.
7	26043155	Taken together, our findings illustrate that TNFAIP3 restricts MTOR signaling and promotes autophagy, providing new insight into the manner in which MTOR and autophagy regulate survival in CD4 T cells.
8	24997049	Exposure of cultured microglia and macrophages to IFN-γ abrogated subsequent IL-10 induction by HSPB5, and strongly promoted HSPB5-triggered release of TNF-α, IL-6, IL-12, IL-1β and reactive oxygen and nitrogen species.
9	24997049	In addition, high levels of CXCL9, CXCL10, CXL11, several guanylate-binding proteins and the ubiquitin-like protein FAT10 were induced by combined activation with IFN-γ and HSPB5.
10	24997049	Together, our data suggest that inflammatory demyelination during MS is selectively associated with IFN-γ-induced re-programming of an otherwise protective response of microglia and macrophages to the endogenous TLR2 agonist HSPB5.
11	24478392	Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on coxsackievirus and adenovirus receptor expression: an explanation of cell sloughing during testicular inflammation in mice.
12	24478392	Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on coxsackievirus and adenovirus receptor expression: an explanation of cell sloughing during testicular inflammation in mice.
13	24478392	Interferon-gamma (IFNG) and tumor necrosis factor alpha (TNF) are two major cytokines that are elevated during testicular inflammation and cause reduced fertility.
14	24478392	Interferon-gamma (IFNG) and tumor necrosis factor alpha (TNF) are two major cytokines that are elevated during testicular inflammation and cause reduced fertility.
15	24478392	We investigated the mechanism by which IFNG and TNF exert their disruptive effects on testicular cell adhesion.
16	24478392	We investigated the mechanism by which IFNG and TNF exert their disruptive effects on testicular cell adhesion.
17	24478392	We have demonstrated that combined treatment with IFNG and TNF (IFNG+TNF) exerts a synergistic effect by downregulating CAR mRNA and protein levels.
18	24478392	We have demonstrated that combined treatment with IFNG and TNF (IFNG+TNF) exerts a synergistic effect by downregulating CAR mRNA and protein levels.
19	24478392	Immunofluorescence staining revealed that IFNG+TNF treatment effectively removes CAR from the site of cell-cell contact.
20	24478392	Immunofluorescence staining revealed that IFNG+TNF treatment effectively removes CAR from the site of cell-cell contact.
21	24478392	Using inhibitor and co-immunoprecipitation, we confirmed that IFNG+TNF mediates CAR protein degradation via ubiquitin-proteasome and NFKB pathways.
22	24478392	Using inhibitor and co-immunoprecipitation, we confirmed that IFNG+TNF mediates CAR protein degradation via ubiquitin-proteasome and NFKB pathways.
23	24478392	Blockage of ubiquitin-proteasome pathway significantly inhibits CAR degradation, as indicated by the reappearance of CAR at the site of cell-cell contact.
24	24478392	Blockage of ubiquitin-proteasome pathway significantly inhibits CAR degradation, as indicated by the reappearance of CAR at the site of cell-cell contact.
25	24478392	Additionally, IFNG+TNF reduces CAR mRNA via transcriptional regulation.
26	24478392	Additionally, IFNG+TNF reduces CAR mRNA via transcriptional regulation.
27	24478392	Mutational studies have shown that IFNG+TNF-induced CAR repression is achieved by suppression of the basal transcription.
28	24478392	Mutational studies have shown that IFNG+TNF-induced CAR repression is achieved by suppression of the basal transcription.
29	24478392	Electrophoretic mobility shift assay and chromatin immunoprecipitation assays further confirmed that IFNG+TNF treament not only inhibits binding of the basal transcription factors but also promotes binding of NFKB subunits and Sp1 (negative regulators) to the CAR promoter region.
30	24478392	Electrophoretic mobility shift assay and chromatin immunoprecipitation assays further confirmed that IFNG+TNF treament not only inhibits binding of the basal transcription factors but also promotes binding of NFKB subunits and Sp1 (negative regulators) to the CAR promoter region.
31	24478392	Taken together, IFNG+TNF treatment significantly downregulates CAR expression, which provides an explanation of how cell sloughing in the epithelium mediates, by loss of CAR-based cell adhesion, during testicular inflammation.
32	24478392	Taken together, IFNG+TNF treatment significantly downregulates CAR expression, which provides an explanation of how cell sloughing in the epithelium mediates, by loss of CAR-based cell adhesion, during testicular inflammation.