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Gene Information
Gene symbol: SETD2
Gene name: SET domain containing 2
HGNC ID: 18420
Synonyms: HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | HIF1A | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | IL17A | 1 hits |
| 5 | IL23R | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26378072 | In standard human Th17 cultures, IL-17 production was restricted to CCR6(+)CD45RA(+) T cells, which expressed CD95 and produced IL-17 ex vivo, identifying them as Th17 memory stem cells. |
| 2 | 26378072 | Uncommitted naive CD4(+) T cells upregulated CCR6, RORC2, and IL-23R expression with Th17-promoting cytokines but in addition required sustained TCR stimulation, late mammalian target of rapamycin (mTOR) activity, and HIF-1α to produce IL-17. |
| 3 | 26084024 | E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. |
| 4 | 26084024 | E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. |
| 5 | 26084024 | Mice with Foxp3-restricted VHL deletion displayed massive inflammation associated with excessive Treg cell interferon-γ (IFN-γ) production. |
| 6 | 26084024 | Mice with Foxp3-restricted VHL deletion displayed massive inflammation associated with excessive Treg cell interferon-γ (IFN-γ) production. |
| 7 | 26084024 | Augmented hypoxia-inducible factor 1α (HIF-1α)-induced glycolytic reprogramming was required for IFN-γ production. |
| 8 | 26084024 | Augmented hypoxia-inducible factor 1α (HIF-1α)-induced glycolytic reprogramming was required for IFN-γ production. |
| 9 | 26084024 | Furthermore, HIF-1α bound directly to the Ifng promoter. |
| 10 | 26084024 | Furthermore, HIF-1α bound directly to the Ifng promoter. |
| 11 | 24010824 | Hypoxia-inducible factor 1α (HIF-1α) has been well established as a protective factor for intestinal barrier function in intestinal epithelial cells. |
| 12 | 24010824 | Hypoxia-inducible factor 1α (HIF-1α) has been well established as a protective factor for intestinal barrier function in intestinal epithelial cells. |
| 13 | 24010824 | We proposed that lymphocyte-derived interferon-gamma (IFN-γ) might be responsible for the intestinal barrier dysfunction caused by increased HIF-1α. |
| 14 | 24010824 | We proposed that lymphocyte-derived interferon-gamma (IFN-γ) might be responsible for the intestinal barrier dysfunction caused by increased HIF-1α. |