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Gene Information
Gene symbol: SLC5A8
Gene name: solute carrier family 5 (iodide transporter), member 8
HGNC ID: 19119
Synonyms: AIT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GPR109A | 1 hits |
| 2 | NOS2A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22517765 | Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. |
| 2 | 22517765 | Butyrate treatment-induced apoptosis of wild-type T cells but not Fas-deficient (Fas(lpr)) or FasL-deficient (Fas(gld)) T cells, revealing a potential role of Fas-mediated apoptosis of T cells as a mechanism of butyrate function. |
| 3 | 22517765 | Histone deacetylase 1 (HDAC1) was found to bind to the Fas promoter in T cells, and butyrate inhibits HDAC1 activity to induce Fas promoter hyperacetylation and Fas upregulation in T cells. |
| 4 | 22517765 | Knocking down gpr109a or slc5a8, the genes that encode for receptor and transporter of butyrate, respectively, resulted in altered expression of genes related to multiple inflammatory signaling pathways, including inducible nitric oxide synthase (iNOS), in mouse colonic epithelial cells in vivo. |
| 5 | 22517765 | Butyrate effectively inhibited IFN-γ-induced STAT1 activation, resulting in inhibition of iNOS upregulation in human colon epithelial and carcinoma cells in vitro. |