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Gene Information
Gene symbol: SLC7A5
Gene name: solute carrier family 7 (amino acid transporter light chain, L system), member 5
HGNC ID: 11063
Synonyms: LAT1, E16, D16S469E, MPE16, CD98
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD69 | 1 hits |
| 3 | IL17A | 1 hits |
| 4 | IL2RA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26582197 | CD4(+) T-cells in systemic lupus erythematosus (SLE) patients show altered T-cell receptor signaling, which utilizes Fc-receptor γ-chain FcRγ-Syk. |
| 2 | 26582197 | In this study, we show that the ICs present in SLE patients by ligating to FcγRIIIa on CD4(+) T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4(+) T-cells in the absence of CD28 signal. |
| 3 | 26582197 | This led to the development of pathogenic IL-17A(+) and IFN-γ(high) CD4(+) T-cells in vitro. |
| 4 | 26582197 | Cytokines IL-1β, IL-6, TGF-β1, and IL-23 were the only requirement for the development of both populations. |
| 5 | 26582197 | SLE patients CD4(+) T-cells that expressed CD25, CD69, and CD98 bound to ICs showed pSyk and produced IFN-γ and IL-17A. |
| 6 | 26582197 | FcγRIIIa-pSyk up-regulated several toll-like receptor genes as well as the HMGB1 and MyD88 gene transcripts. |