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Gene Information
Gene symbol: SMAD7
Gene name: SMAD family member 7
HGNC ID: 6773
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CHI3L1 | 1 hits |
| 2 | SIRT1 | 1 hits |
| 3 | STAT3 | 1 hits |
| 4 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27670768 | Microarray revealed changes in gene expression: four genes were downregulated (B3GNT3, ZNF683, IFNG and TNF) and seven upregulated (DEFA4, CTSG, DEFA8P, AZU1, MPO, ELANE and PRTN3). |
| 2 | 27670768 | Comparison with previously published data on in vitro methylprednisolone-regulated genes showed that SMAD7, TNF and CHI3L1 were also downregulated in vivo in relapsing-remitting multiple sclerosis patients. |
| 3 | 24850427 | SIRT1, a class III NAD+-dependent deacetylase, regulates negatively the expression of various proteins involved in the control of immune-inflammatory pathways, such as Stat3, Smad7, and NF-κB. |
| 4 | 24850427 | SIRT1 expression was downregulated in control LPMC by tumor necrosis factor (TNF)-α and interleukin (IL)-21, and upregulated in IBD LPMC by neutralizing TNF-α and IL-21antibodies. |
| 5 | 24850427 | Treatment of IBD LPMC with Cay10591, a specific SIRT1 activator, reduced NF-κB activation and inhibited inflammatory cytokine synthesis, whereas Ex527, an inhibitor of SIRT1, increased interferon (IFN)-γ in control LPMC. |