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Gene Information
Gene symbol: SOCS3
Gene name: suppressor of cytokine signaling 3
HGNC ID: 19391
Synonyms: SSI-3, CIS3, SOCS-3, Cish3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CPT2 | 1 hits |
| 2 | CXCL10 | 1 hits |
| 3 | CXCR3 | 1 hits |
| 4 | FABP5 | 1 hits |
| 5 | ICAM1 | 1 hits |
| 6 | IFN1 | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IL10 | 1 hits |
| 9 | JAK1 | 1 hits |
| 10 | SOCS1 | 1 hits |
| 11 | STAT1 | 1 hits |
| 12 | STAT3 | 1 hits |
| 13 | TBX21 | 1 hits |
| 14 | TCF7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28505074 | PCR array showed upregulation of some genes involved in lipid metabolism and anti-inflammatory activity (Cpt2, Ifng) and downregulation of some genes involved in pro-inflammatory response and in free fatty acid up-take (Fabp5, Socs3). |
| 2 | 28316372 | The expression of genes, including IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1, and IRF1, was investigated by RT-qPCR. |
| 3 | 28316372 | Patients with dyslipidemia demonstrated statistically higher expression of the IL10 and IFNA genes, while IFNG, IP10, IRF1, JAK1, and STAT3 were lower in comparison with nondyslipidemic patients. |
| 4 | 21518797 | The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. |
| 5 | 21518797 | The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype. |
| 6 | 21518797 | In this study, we first identify Socs1, Socs3, and Tcf7 (TCF-1) as gene targets that are negatively regulated by T-bet. |
| 7 | 21518797 | Consistent with this, we identified two T-bet DNA-binding elements in the Socs1 promoter that are functionally used to down-regulate transcription in primary Th1 cells. |
| 8 | 21518797 | Furthermore, T-bet functionally recruits Bcl-6 to the Ifng locus in late stages of Th1 differentiation to repress its activity, possibly to prevent the overproduction of IFN-γ, which could result in autoimmunity. |