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Gene Information
Gene symbol: SP1
Gene name: Sp1 transcription factor
HGNC ID: 11205
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | PRKAR1A | 1 hits |
| 3 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24478392 | Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on coxsackievirus and adenovirus receptor expression: an explanation of cell sloughing during testicular inflammation in mice. |
| 2 | 24478392 | Interferon-gamma (IFNG) and tumor necrosis factor alpha (TNF) are two major cytokines that are elevated during testicular inflammation and cause reduced fertility. |
| 3 | 24478392 | We investigated the mechanism by which IFNG and TNF exert their disruptive effects on testicular cell adhesion. |
| 4 | 24478392 | We have demonstrated that combined treatment with IFNG and TNF (IFNG+TNF) exerts a synergistic effect by downregulating CAR mRNA and protein levels. |
| 5 | 24478392 | Immunofluorescence staining revealed that IFNG+TNF treatment effectively removes CAR from the site of cell-cell contact. |
| 6 | 24478392 | Using inhibitor and co-immunoprecipitation, we confirmed that IFNG+TNF mediates CAR protein degradation via ubiquitin-proteasome and NFKB pathways. |
| 7 | 24478392 | Blockage of ubiquitin-proteasome pathway significantly inhibits CAR degradation, as indicated by the reappearance of CAR at the site of cell-cell contact. |
| 8 | 24478392 | Additionally, IFNG+TNF reduces CAR mRNA via transcriptional regulation. |
| 9 | 24478392 | Mutational studies have shown that IFNG+TNF-induced CAR repression is achieved by suppression of the basal transcription. |
| 10 | 24478392 | Electrophoretic mobility shift assay and chromatin immunoprecipitation assays further confirmed that IFNG+TNF treament not only inhibits binding of the basal transcription factors but also promotes binding of NFKB subunits and Sp1 (negative regulators) to the CAR promoter region. |
| 11 | 24478392 | Taken together, IFNG+TNF treatment significantly downregulates CAR expression, which provides an explanation of how cell sloughing in the epithelium mediates, by loss of CAR-based cell adhesion, during testicular inflammation. |