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Gene Information
Gene symbol: TANK
Gene name: TRAF family member-associated NFKB activator
HGNC ID: 11562
Synonyms: I-TRAF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | TBK1 | 1 hits |
| 2 | TNFAIP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25217635 | A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels. |
| 2 | 25217635 | In gain- and loss-of-function studies, A20 inversely regulated expression of IFNγ-induced atherogenic genes in human EC and SMC by modulating STAT1 transcription. |
| 3 | 25217635 | Transcriptome analysis of the aortic media from A20 heterozygote versus wild-type mice revealed increased basal Ifnβ signaling as the likely cause for higher Stat1 transcription. |
| 4 | 25217635 | We confirmed higher basal IFNβ levels in A20-silenced human SMC and showed that neutralization or knockdown of IFNβ abrogates heightened STAT1 levels in these cells. |
| 5 | 25217635 | Upstream of IFNβ, A20-silenced EC and SMC demonstrated higher levels of phosphorylated/activated TANK-binding kinase-1 (TBK1), a regulator of IFNβ transcription. |
| 6 | 25217635 | This suggested that A20 knockdown increased STAT1 transcription by enhancing TBK1 activation and subsequently basal IFNβ levels. |
| 7 | 25217635 | Altogether, these results uncover A20 as a key physiologic regulator of atherogenic IFNγ/STAT1 signaling. |