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Gene Information
Gene symbol: TCF7
Gene name: transcription factor 7 (T-cell specific, HMG-box)
HGNC ID: 11639
Synonyms: TCF-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SOCS1 | 1 hits |
| 2 | SOCS3 | 1 hits |
| 3 | TBX21 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21518797 | The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. |
| 2 | 21518797 | The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype. |
| 3 | 21518797 | In this study, we first identify Socs1, Socs3, and Tcf7 (TCF-1) as gene targets that are negatively regulated by T-bet. |
| 4 | 21518797 | Consistent with this, we identified two T-bet DNA-binding elements in the Socs1 promoter that are functionally used to down-regulate transcription in primary Th1 cells. |
| 5 | 21518797 | Furthermore, T-bet functionally recruits Bcl-6 to the Ifng locus in late stages of Th1 differentiation to repress its activity, possibly to prevent the overproduction of IFN-γ, which could result in autoimmunity. |