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Gene Information
Gene symbol: TET2
Gene name: tet methylcytosine dioxygenase 2
HGNC ID: 25941
Synonyms: FLJ20032
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DNMT3A | 1 hits |
| 2 | IDH2 | 1 hits |
| 3 | RHOA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26268241 | We performed targeted resequencing on 92 cases of PTCL and identified frequent mutations affecting RHOA, TET2, DNMT3A, and isocitrate dehydrogenase 2 (IDH2). |
| 2 | 26268241 | Strikingly, AITL cases with IDH2(R172) mutations demonstrated a distinct gene expression signature characterized by downregulation of genes associated with TH1 differentiation (eg, STAT1 and IFNG) and a striking enrichment of an interleukin 12-induced gene signature. |
| 3 | 26268241 | Ectopic expression of IDH2(R172K) in the Jurkat cell line and CD4(+) T cells led to markedly increased levels of 2-hydroxyglutarate, histone-3 lysine methylation, and 5-methylcytosine and a decrease of 5-hydroxymethylcytosine. |