Ignet

Gene Information

Gene symbol: TLR1

Gene name: toll-like receptor 1

HGNC ID: 11847

Synonyms: rsc786, KIAA0012, CD281

Related Genes

#	Gene Symbol	Number of hits
1	ANGPT2	1 hits
2	CD14	1 hits
3	CORO1A	1 hits
4	CSF2	1 hits
5	DUSP14	1 hits
6	FCN2	1 hits
7	HMGB1	1 hits
8	HSPA1B	1 hits
9	HSPA1L	1 hits
10	IFNG	1 hits
11	IL10	1 hits
12	IL17F	1 hits
13	IL18	1 hits
14	IL18R1	1 hits
15	IL1A	1 hits
16	IL1B	1 hits
17	IL1RN	1 hits
18	IL4	1 hits
19	IL6	1 hits
20	IL8	1 hits
21	ISG15	1 hits
22	LTA	1 hits
23	MASP2	1 hits
24	MBL2	1 hits
25	MYLK	1 hits
26	NOD2	1 hits
27	NOS2A	1 hits
28	SERPINE1	1 hits
29	SLC11A1	1 hits
30	SOD2	1 hits
31	STAT1	1 hits
32	TLR2	1 hits
33	TLR4	1 hits
34	TLR9	1 hits
35	TNF	1 hits
36	TNFAIP2	1 hits
37	VDR	1 hits

Related Sentences

#	PMID	Sentence
1	28715406	Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.
2	28715406	From the 15 single nucleotide polymorphisms (SNPs) at the 8 candidate genes genotyped (TNF/LTA, IFNG, IL10, TLR1, NOD2, SOD2, and IL6) we observed statistically different survival curves for rs751271 at the NOD2 and rs2069845 at the IL6 genes (log-rank p-values = 0.002 and 0.023, respectively), suggesting an influence on the amount of time before developing leprosy reactions.
3	28715406	Cox models showed associations between the SNPs rs751271 at NOD2 and rs2069845 at IL6 with leprosy reactions (HRGT = 0.45, p = 0.002; HRAG = 1.88, p = 0.0008, respectively).
4	28715406	Finally, IL-6 and IFN-γ levels were confirmed as high, while IL-10 titers were low in the sera of reactional patients.
5	28715406	From the results, we conclude that SNPs at the NOD2 and IL6 genes are associated with leprosy reactions as an outcome.
6	26559095	Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification.
7	26473437	The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
8	26261240	V75M, one of many disease-causing mutations occurring in SUMO*motif (72-ψψψψKDxxxxSY-83) of WASp, compromises WASp-SUMOylation, associates with COMMD1 to attenuate NF-κB signaling, and recruits histone deacetylases-6 (HDAC6) to p300-marked promoters of NF-κB response genes that pattern immunity but not inflammation.
9	26261240	Consequently, proteins mediating adaptive immunity (IFNG, STAT1, TLR1) are deficient, whereas those mediating auto-inflammation (GM-CSF, TNFAIP2, IL-1β) are paradoxically increased in TH1 cells expressing SUMOylation-deficient WASp.
10	26261240	Moreover, SUMOylation-deficient WASp favors ectopic development of the TH17-like phenotype (↑IL17A, IL21, IL22, IL23R, RORC, and CSF2) under TH1-skewing conditions, suggesting a role for WASp in modulating TH1/TH17 plasticity.
11	24751285	IFNG, TLR1), or by sampling exons from genes spaced evenly across chromosomes.