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Gene Information
Gene symbol: TNFAIP2
Gene name: tumor necrosis factor, alpha-induced protein 2
HGNC ID: 11895
Synonyms: B94, EXOC3L3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSF2 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL1B | 1 hits |
| 4 | STAT1 | 1 hits |
| 5 | TLR1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26261240 | V75M, one of many disease-causing mutations occurring in SUMO*motif (72-ψψψψKDxxxxSY-83) of WASp, compromises WASp-SUMOylation, associates with COMMD1 to attenuate NF-κB signaling, and recruits histone deacetylases-6 (HDAC6) to p300-marked promoters of NF-κB response genes that pattern immunity but not inflammation. |
| 2 | 26261240 | Consequently, proteins mediating adaptive immunity (IFNG, STAT1, TLR1) are deficient, whereas those mediating auto-inflammation (GM-CSF, TNFAIP2, IL-1β) are paradoxically increased in TH1 cells expressing SUMOylation-deficient WASp. |
| 3 | 26261240 | Moreover, SUMOylation-deficient WASp favors ectopic development of the TH17-like phenotype (↑IL17A, IL21, IL22, IL23R, RORC, and CSF2) under TH1-skewing conditions, suggesting a role for WASp in modulating TH1/TH17 plasticity. |