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Gene Information
Gene symbol: TOP2A
Gene name: topoisomerase (DNA) II alpha 170kDa
HGNC ID: 11989
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2113589 | When used in combination with interferon gamma (IFNG) or chemotherapeutic drugs targeted at DNA topoisomerase II, synergistic cytotoxicity has been observed. |
| 2 | 2113589 | The cytotoxicity of TNF and low dose actinomycin-D (AMD) against MBT-2 in vitro was examined alone and following preincubation with IFNG. |
| 3 | 2113589 | The activity of TNF/AMD in vivo utilizing an intravesical implantation mode (MBT-2) was also evaluated. |
| 4 | 2113589 | TNF/AMD was cytotoxic for MBT-2 growth in vitro. |
| 5 | 2113589 | A two hour preincubation with IFNG markedly increased the cytotoxicity of TNF/AMD whereas longer incubations did not enhance cytotoxic activity. |
| 6 | 2113589 | This study demonstrated that TNF/AMD exhibits cytotoxicity for MBT-2 cells in vitro but is ineffective in reducing implantation of intravesical tumors in vivo. |
| 7 | 2113589 | The in vitro data suggest brief exposure of MBT-2 cells to IFNG augments the subsequent anti-tumor activity of TNF/AMD. |