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Gene Information
Gene symbol: TRA
Gene name: T cell receptor alpha locus
HGNC ID: 12027
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | PIK3CG | 1 hits |
| 3 | PTK2B | 1 hits |
| 4 | TRB | 1 hits |
| 5 | TYK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25387834 | Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells. |
| 2 | 25387834 | We have previously shown that Pyk2 is activated downstream of the TCR in a PI3K-independent manner. |
| 3 | 25387834 | We observed that Pyk2 localized with the p85 regulatory subunit of PI3K at the LAT complex and that PI3K-dependent signaling was impaired in Pyk2-deficient T cells. |
| 4 | 25387834 | Likewise, functions downstream of PI3K, including IFN-γ production and proliferation, were also suppressed in human T cells deficient in Pyk2. |
| 5 | 25387834 | Collectively, these data demonstrate that Pyk2 is a critical regulator of PI3K function downstream of the TCR. |
| 6 | 22116824 | The 1MOG244 T cell expresses dual TCRA chains, one of which, when combined with the single TCRB present, promotes the development of CD8(+) T cells with specificity for hair follicles. |
| 7 | 22116824 | Pathologic T cells primarily express IFNG and IL-17 early in disease, with dramatic increases in cytokine production and recruitment of IL-4 and IL-10 production with disease progression. |