- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: TYMS
Gene name: thymidylate synthetase
HGNC ID: 12441
Synonyms: Tsase, TMS, HsT422
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EGFR | 1 hits |
| 2 | ERAL1 | 1 hits |
| 3 | ESR1 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IGF1 | 1 hits |
| 6 | IL1R1 | 1 hits |
| 7 | IL1RN | 1 hits |
| 8 | MMP3 | 1 hits |
| 9 | SLC6A3 | 1 hits |
| 10 | UGT1A1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18068529 | To determine ancestral allele in possible cancer-associated polymorphisms, DNA samples from 10 chimpanzees (Pan troglodytes) were sequenced for alleles corresponding to 17 polymorphisms: 8 short tandem repeats [IL1RN (alias IL-1RA) variable number tandem repeat (VNTR); TYMS (previously TS) VNTR; AR CAG repeat; dinucleotide repeats of UGT1A1, IGF1, IFNG (alias IFN-gamma), ESR1 (alias ER-alpha), and EGFR] and 9 single nucleotide polymorphisms (MMP1-1607 1G/2G, MMP3-1171 5A/6A, OGG1 Ser326Cys, ALDH2 Gly487Lys, TP53 Arg72Pro, ABCG2 Gln141Lys, MGMT Leu84Phe, SOD2 Ala-9Val, and MTHFR Ala222Val). |
| 2 | 18068529 | Dinucleotide repeat polymorphisms of IGF1, IFNG, ESR1, and EGFR were shared by chimpanzees, but the length of repeats tended to be longer in humans than in chimpanzees. |
| 3 | 18068529 | Thus, all of the possible cancer-associated polymorphisms tested have human-specific alleles, and the ancestral allele is lost in three polymorphisms (IL1RN VNTR, UGT1A1 CA repeat, and MMP3-1171 5A/6A), suggesting a possible involvement of human-specific alleles in cancer susceptibility. |