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Gene Information
Gene symbol: ZNF395
Gene name: zinc finger protein 395
HGNC ID: 18737
Synonyms: PRF-1, HDBP2, PBF, DKFZp434K1210
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCR5 | 1 hits |
| 2 | CD27 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | CXCR3 | 1 hits |
| 5 | EOMES | 1 hits |
| 6 | GZMB | 1 hits |
| 7 | IFNAR1 | 1 hits |
| 8 | IFNG | 1 hits |
| 9 | IFNGR1 | 1 hits |
| 10 | IL1B | 1 hits |
| 11 | IL6 | 1 hits |
| 12 | IL7R | 1 hits |
| 13 | KLRD1 | 1 hits |
| 14 | PRF1 | 1 hits |
| 15 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21278341 | We sought to understand transcriptional control of the effector genes IFN-γ (Ifng), granzyme B (Gzmb), and perforin 1 (Prf1) in murine memory CD8(+) T cells by characterizing their transcriptional profiles and chromatin states during lymphocytic choriomeningitis virus infection. |
| 2 | 21278341 | Primary infection leads to reduced nucleosomal density near the transcription start sites and reduced H3K27 methylation throughout the Ifng and Gzmb loci, and these chromatin changes persist in the memory phase. |
| 3 | 21278341 | Despite similarities in chromatin at the memory stage, PolII recruitment and continuous transcription occur at the Ifng locus but not the Gzmb locus. |
| 4 | 22735807 | We have previously shown that vaccination with the natural tumor peptide Melan-A-induced T cells with superior effector functions as compared with vaccination with the analog peptide optimized for enhanced HLA-A*0201 binding. |
| 5 | 22735807 | Here we found that natural peptide vaccination induced tumor-reactive CD8 T cells with frequent coexpression of both memory/homing-associated genes (CD27, IL7R, EOMES, CXCR3, and CCR5) and effector-related genes (IFNG, KLRD1, PRF1, and GZMB), comparable with protective Epstein-Barr virus-specific and cytomegalovirus-specific T cells. |
| 6 | 26625258 | In the complete response (CR) cases, 999 overexpressed genes including at least 234 tumor-specific CTL-activation associated genes such as IFNG, PRF1, and GZMB, were found in post-treatment biopsy specimens. |
| 7 | 26625258 | Furthermore, NK cells, which were activated by neutrophils-producing S100A8/S100A9, and CTLs were suggested to cooperatively enhance the effect of CRT in the CDH2-negative I-type. |
| 8 | 27774523 | To test how perforin (Prf1), granzyme B (GzmB) and interferon-gamma (IFNg) impact tumor occurrence and progression, we bred the TgMISIIR-TAg transgene into Prf1-/-, GzmB-/-, and IFNgR1-/- mice. |
| 9 | 27774523 | In contrast, loss of function of Prf1 or GzmB did not significantly impact tumor progression and host survival. |
| 10 | 27774523 | To test how perforin (Prf1), granzyme B (GzmB) and interferon-gamma (IFNg) impact tumor occurrence and progression, we bred the TgMISIIR-TAg transgene into Prf1-/-, GzmB-/-, and IFNgR1-/- mice. |
| 11 | 27774523 | In contrast, loss of function of Prf1 or GzmB did not significantly impact tumor progression and host survival. |
| 12 | 27855206 | However, whereas IFNAR KO mice showed infiltration by neutrophils and macrophages and higher expression of IL-1, IL-6 and Cox2, B6 WT mice show a cellular infiltration in the CNS composed predominantly of T cells, particularly CD8+ T cells, and increased mRNA expression levels of IFNg, GzmB and Prf1 at peak of disease. |
| 13 | 28220815 | Here, we demonstrate that in CD8+ T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. |
| 14 | 28220815 | In tumors obtained from Cbx3/HP1γ-insufficient mice or wild type mice treated with Cbx3/HP1γ-insufficient CD8+ T cells, there is an increase of CD8+ effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4+ CD25+ FOXP3+ regulatory T cells (Treg cells) as well as CD25+ CD4+ T cells expressing the inhibitory receptor CTLA4. |