Ignet

Gene Information

Gene symbol: C19orf10

Gene name: chromosome 19 open reading frame 10

HGNC ID: 16948

Synonyms: R33729_1, IL25, SF20, IL-25, IL-27

Related Genes

#	Gene Symbol	Number of hits
1	ADAM33	1 hits
2	CD4	1 hits
3	CSF2	1 hits
4	IFNA13	1 hits
5	IFNAR2	1 hits
6	IL12A	1 hits
7	IL17D	1 hits
8	IL23A	1 hits
9	IL27	1 hits
10	NFKBIA	1 hits
11	STAT2	1 hits
12	TGFBR1	1 hits

Related Sentences

#	PMID	Sentence
1	19258923	We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
2	21516112	Here we report that interleukin 23 (IL-23) and the transcription factor RORγt drove expression of the cytokine GM-CSF in helper T cells, whereas IL-12, interferon-γ (IFN-γ) and IL-27 acted as negative regulators.
3	21516112	Autoreactive helper T cells specifically lacking GM-CSF failed to initiate neuroinflammation despite expression of IL-17A or IFN-γ, whereas GM-CSF secretion by Ifng(-/-)Il17a(-/-) helper T cells was sufficient to induce experimental autoimmune encephalomyelitis (EAE).
4	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
5	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
6	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
7	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
8	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
9	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
10	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
11	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
12	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
13	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
14	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
15	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
16	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
17	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
18	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
19	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
20	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
21	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
22	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
23	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
24	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
25	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
26	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
27	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
28	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
29	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
30	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
31	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
32	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
33	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
34	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
35	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
36	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
37	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
38	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
39	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
40	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
41	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
42	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
43	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
44	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
45	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
46	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
47	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
48	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
49	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
50	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
51	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
52	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.