Ignet

Gene Information

Gene symbol: CD80

Gene name: CD80 molecule

HGNC ID: 1700

Synonyms: B7.1, B7-1

Related Genes

#	Gene Symbol	Number of hits
1	CD40	1 hits
2	CD40LG	1 hits
3	CD86	1 hits
4	HLA-A	1 hits
5	IL10	1 hits
6	IL15	1 hits

Related Sentences

#	PMID	Sentence
1	11022132	For this purpose, DC were enriched from blood of healthy donors by the use of the adherence method, and expression of surface molecules and intracellular IFN-g, IL-10, IL-12 and IL-15 was studied by flow cytometry.
2	11022132	Enriched blood DC expressed higher levels of IFN-g, IL-12 and IL-15, compared to whole mononuclear cells (MNC) incubated for the same time.
3	11022132	Expression of IFN-g and IL-12 was confined to the mature CD83+CD11c+ DC subset.
4	11022132	Enriched DC from females' blood displayed higher levels of CD80, IL-10 and IL-15.
5	11022132	Taken together, enriched blood DC spontaneously express larger amounts of IFN-g, IL-12 and IL-15 than MNC.
6	11022132	Sex differences in expression of CD80, IL-10 and IL-15 may have a modulatory influence on immune responses in males and females.
7	11022132	For this purpose, DC were enriched from blood of healthy donors by the use of the adherence method, and expression of surface molecules and intracellular IFN-g, IL-10, IL-12 and IL-15 was studied by flow cytometry.
8	11022132	Enriched blood DC expressed higher levels of IFN-g, IL-12 and IL-15, compared to whole mononuclear cells (MNC) incubated for the same time.
9	11022132	Expression of IFN-g and IL-12 was confined to the mature CD83+CD11c+ DC subset.
10	11022132	Enriched DC from females' blood displayed higher levels of CD80, IL-10 and IL-15.
11	11022132	Taken together, enriched blood DC spontaneously express larger amounts of IFN-g, IL-12 and IL-15 than MNC.
12	11022132	Sex differences in expression of CD80, IL-10 and IL-15 may have a modulatory influence on immune responses in males and females.
13	19283894	In vitro, it inhibited the binding of both human and murine CD154 (CD40L) to their receptor (CD40) even in the presence of protein-containing media and prevented the CD154-induced proliferation of human B cells as well as the corresponding increase in surface expression of CD86, CD80, CD40, and MHC class II in a concentration-dependent manner.
14	19283894	Furthermore, in isolated human islets, it also decreased the CD154-induced release of inflammatory cytokines such as IFN-g, interleukin-6 (IL-6), and IL-8.
15	19283894	Suramin was selected for investigation because it has been reported to be an inhibitor of the interaction of TNF-a with its receptor and CD154 is a member of the TNF-family.
16	20621581	Epinephrine-primed murine bone marrow-derived dendritic cells facilitate production of IL-17A and IL-4 but not IFN-γ by CD4+ T cells.
17	20621581	Epinephrine pre-treatment enhanced surface expression of MHCII, CD80 and CD86.
18	20621581	Epinephrine pre-treatment also induced a significant decrease of IL-12p70 and a significant increase of IL-23 and IL-10 cytokine production.
19	20621581	Importantly, these changes corresponded with increased IL-4 and IL-17A, but not IFN-g cytokine production by CD4(+) T cells in a b2-adrenergic receptor-dependent manner.
20	23521696	Recently, the programmed death 1/programmed death 1 ligand (PD-1/PD-L1; CD279/CD274) pathway was demonstrated to play a critical role in attenuating T-cell responses and promoting T-cell tolerance during chronic viral infections.
21	23521696	In this study, we examined the expression of PD-1 and PD-L1 on cervical T cells and dendritic cells (DCs), respectively, from 40 women who were HR-HPV-negative (-) or HR-HPV-positive (+) with CIN grades 0, I and II-III.
22	23521696	We also measured interferon-γ, interleukin-12 (IL-12) and IL-10 in cervical exudates.
23	23521696	PD-1 and PD-L1 expression on cervical T cells and DCs, respectively, was associated with HR-HPV positivity and increased in parallel with increasing CIN grade.
24	23521696	The opposite pattern was observed for CD80 and CD86 expression on DCs, which decreased in HR-HPV+ patients in parallel with increasing CIN grade.
25	23521696	Similarly, reduced levels of the T helper type 1 cytokines interferon-γ and IL-12 and increased levels of the T helper type 2 cytokine IL-10 in cervical exudates correlated with HR-HPV positivity and CIN grade.
26	23521696	Our results suggest that up-regulation of the inhibitory PD-1/PD-L1 pathway may negatively regulate cervical cell-mediated immunity to HPV and contribute to the progression of HR-HPV-related CIN.
27	23521696	These results may aid in the development of PD-1/PD-L1 pathway-based strategies for immunotherapy of HR-HPV-related CIN.