Ignet

Gene Information

Gene symbol: COL1A1

Gene name: collagen, type I, alpha 1

HGNC ID: 2197

Synonyms: OI4

Related Genes

#	Gene Symbol	Number of hits
1	ASF1A	1 hits
2	CD44	1 hits
3	DLL3	1 hits
4	FZD9	1 hits
5	GBP2	1 hits
6	GLI1	1 hits
7	GLI2	1 hits
8	IFNG	1 hits
9	IL17A	1 hits
10	IL17B	1 hits
11	INDO	1 hits
12	KRT5	1 hits
13	NOTCH2	1 hits
14	NOTCH3	1 hits
15	NUMB	1 hits
16	NUMBL	1 hits
17	TNFRSF11B	1 hits

Related Sentences

#	PMID	Sentence
1	12849703	The cells were then analyzed for the effects of non-thermal ultrasound on cell growth and the presence of IL-2, IL-4 and IFN-g.
2	12849703	Cells pre-treated with 1 MHz and stimulated with ConA showed a significant increase in IL-4 and IFN-g.
3	12849703	Conversely, cells pre-treated with 3 MHz and stimulated with ConA show a significant decrease in IL-4 and IFN-g.
4	12849703	Interferon-gamma is known to stimulate production of collagen in fibroblasts, enhance debridement activity of macrophage and inhibit activity of the T cell subpopulation, T(H2).
5	19302234	K562/A02 cells showed a 65-fold higher IC(50) to adriamycin and less intracellular accumulation of adriamycin than K562. cDNA microarray showed marked increases in binding of collagen and cell proliferation-related genes (CD44, DLL3, IL17B, NUMB, and NUMBL) and decreases in signal transduction and transcription factor activity related genes (FZD9, GBP2, GLI1, GLI2, IFNG, KRT5, Notch2, and Notch3).
6	23613752	Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
7	23613752	C57BL/6 mice are known to be resistant to the development of collagen-induced arthritis (CIA).
8	23613752	Also, production of IL-17 by the splenocytes of the IFN-γ KO mice was increased when cultured with type II collagen.
9	23613752	The proportion of CD44(high)CD62L(low) memory-like T cells were elevated in the spleen, draining lymph node and mesenteric lymph node of IFN-γ KO CIA mice.
10	23613752	Meanwhile, CD44(low)CD62L(high) naïve T cells were increased in IFN-γ and IL-17 double KO CIA mice.
11	23613752	When Th17 polarized CD4+ T cells of IFN-γ KO mice were co-cultured with their own antigen presenting cells (APCs), a greater increase in IL-17 production was observed than in co-culture of the cells from wild type mice.
12	23613752	Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
13	23613752	C57BL/6 mice are known to be resistant to the development of collagen-induced arthritis (CIA).
14	23613752	Also, production of IL-17 by the splenocytes of the IFN-γ KO mice was increased when cultured with type II collagen.
15	23613752	The proportion of CD44(high)CD62L(low) memory-like T cells were elevated in the spleen, draining lymph node and mesenteric lymph node of IFN-γ KO CIA mice.
16	23613752	Meanwhile, CD44(low)CD62L(high) naïve T cells were increased in IFN-γ and IL-17 double KO CIA mice.
17	23613752	When Th17 polarized CD4+ T cells of IFN-γ KO mice were co-cultured with their own antigen presenting cells (APCs), a greater increase in IL-17 production was observed than in co-culture of the cells from wild type mice.
18	23613752	Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
19	23613752	C57BL/6 mice are known to be resistant to the development of collagen-induced arthritis (CIA).
20	23613752	Also, production of IL-17 by the splenocytes of the IFN-γ KO mice was increased when cultured with type II collagen.
21	23613752	The proportion of CD44(high)CD62L(low) memory-like T cells were elevated in the spleen, draining lymph node and mesenteric lymph node of IFN-γ KO CIA mice.
22	23613752	Meanwhile, CD44(low)CD62L(high) naïve T cells were increased in IFN-γ and IL-17 double KO CIA mice.
23	23613752	When Th17 polarized CD4+ T cells of IFN-γ KO mice were co-cultured with their own antigen presenting cells (APCs), a greater increase in IL-17 production was observed than in co-culture of the cells from wild type mice.
24	24222748	Local gene transfer of OPG prevents joint damage and disease progression in collagen-induced arthritis.
25	24222748	This study examined the influence of osteoprotegerin (OPG) gene transfer on a murine collagen-induced arthritis model.
26	24222748	MicroCT data suggested significant protection against subchondral bone mineral density changes in OPG treated CIA mice.
27	24222748	Interestingly, mRNA expressions of IFN-g and MMP3 were noticeably diminished following OPG gene transfer.
28	24222748	Overall, gene transfer of OPG effectively inhibited the arthritis-associated periarticular bone erosion and preserved the architecture of arthritic joints, and the study provides evidence that the cartilage protection of the OPG gene therapy may be associated with the down-regulation of MMP3 expression.
29	24222748	Local gene transfer of OPG prevents joint damage and disease progression in collagen-induced arthritis.
30	24222748	This study examined the influence of osteoprotegerin (OPG) gene transfer on a murine collagen-induced arthritis model.
31	24222748	MicroCT data suggested significant protection against subchondral bone mineral density changes in OPG treated CIA mice.
32	24222748	Interestingly, mRNA expressions of IFN-g and MMP3 were noticeably diminished following OPG gene transfer.
33	24222748	Overall, gene transfer of OPG effectively inhibited the arthritis-associated periarticular bone erosion and preserved the architecture of arthritic joints, and the study provides evidence that the cartilage protection of the OPG gene therapy may be associated with the down-regulation of MMP3 expression.