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Gene Information
Gene symbol: GLI2
Gene name: GLI family zinc finger 2
HGNC ID: 4318
Synonyms: THP2, HPE9, THP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD44 | 1 hits |
| 2 | COL1A1 | 1 hits |
| 3 | DLL3 | 1 hits |
| 4 | FZD9 | 1 hits |
| 5 | GBP2 | 1 hits |
| 6 | GLI1 | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IL17B | 1 hits |
| 9 | KRT5 | 1 hits |
| 10 | NOTCH2 | 1 hits |
| 11 | NOTCH3 | 1 hits |
| 12 | NUMB | 1 hits |
| 13 | NUMBL | 1 hits |
| 14 | SOCS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19302234 | K562/A02 cells showed a 65-fold higher IC(50) to adriamycin and less intracellular accumulation of adriamycin than K562. cDNA microarray showed marked increases in binding of collagen and cell proliferation-related genes (CD44, DLL3, IL17B, NUMB, and NUMBL) and decreases in signal transduction and transcription factor activity related genes (FZD9, GBP2, GLI1, GLI2, IFNG, KRT5, Notch2, and Notch3). |
| 2 | 24058673 | Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells. |
| 3 | 24058673 | Here we show that SOCS1 is a direct target of Hh/GLI signaling in human keratinocytes and medulloblastoma cells. |
| 4 | 24058673 | SOCS1 is a potent inhibitor of interferon gamma (IFN-y)/STAT1 signaling. |
| 5 | 24058673 | The transcription factors GLI1 and GLI2 activate the SOCS1 promoter, which contains five putative GLI binding sites, and GLI2 binding to the promoter was shown by chromatin immunoprecipitation. |
| 6 | 24058673 | Consistent with a role of GLI in SOCS1 regulation, STAT1 phosphorylation is reduced in cells with active Hh/GLI signaling and IFN-у/STAT1 target gene activation is decreased. |
| 7 | 24058673 | Here, we identify SOCS1 as a novel Hh/GLI target gene, indicating a negative role of Hh/GLI pathway in IFN-y/STAT1 signaling. |