Ignet

Gene Information

Gene symbol: IL17D

Gene name: interleukin 17D

HGNC ID: 5984

Synonyms: IL-22, IL-27, IL-17D, IL27, FLJ30846

Related Genes

#	Gene Symbol	Number of hits
1	C19orf10	1 hits
2	CCL2	1 hits
3	CD4	1 hits
4	CSF2	1 hits
5	CXCL1	1 hits
6	CXCL2	1 hits
7	DEFB1	1 hits
8	DYRK2	1 hits
9	IFNG	1 hits
10	IFNGR1	1 hits
11	IFNGR2	1 hits
12	IL10	1 hits
13	IL12A	1 hits
14	IL12RB1	1 hits
15	IL12RB2	1 hits
16	IL13	1 hits
17	IL17A	1 hits
18	IL17F	1 hits
19	IL1B	1 hits
20	IL22	1 hits
21	IL22RA1	1 hits
22	IL23A	1 hits
23	IL23R	1 hits
24	IL26	1 hits
25	IL27	1 hits
26	IL31	1 hits
27	IL6	1 hits
28	MDM1	1 hits
29	REG3G	1 hits
30	REN	1 hits
31	SLPI	1 hits

Related Sentences

#	PMID	Sentence
1	12486605	Among these the most striking ones are the genes coding for the cytokines interleukin-22 (IL-22) and interleukin-26 (IL-26) that constitute together with IFNG a cytokine cluster on chromosome 12q14.
2	15858598	Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region.
3	15858598	We began by analysing West African and European haplotype structure and patterns of linkage disequilibrium across a 100 kb genomic region encompassing IFNG and its immediate neighbours IL22 and IL26.
4	15858598	A large case-control study of severe malaria in a West Africa population identified several weak associations with individual single-nucleotide polymorphisms in the IFNG and IL22 genes, and defined two IL22 haplotypes that are, respectively, associated with resistance and susceptibility.
5	15858598	Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region.
6	15858598	We began by analysing West African and European haplotype structure and patterns of linkage disequilibrium across a 100 kb genomic region encompassing IFNG and its immediate neighbours IL22 and IL26.
7	15858598	A large case-control study of severe malaria in a West Africa population identified several weak associations with individual single-nucleotide polymorphisms in the IFNG and IL22 genes, and defined two IL22 haplotypes that are, respectively, associated with resistance and susceptibility.
8	17483407	Il22, a member of the IL-10 cytokine family, is a candidate gene for the control of mortality during the acute encephalomyelitis.
9	20947410	Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
10	20947410	IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines.
11	20947410	The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22).
12	20947410	IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells.
13	20947410	It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains.
14	20947410	Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes.
15	20947410	Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
16	20947410	IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines.
17	20947410	The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22).
18	20947410	IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells.
19	20947410	It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains.
20	20947410	Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes.
21	21328101	Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls.
22	21328101	Therefore, in the following study, the genes coding interferon gamma (IFNG), IFNG receptor 1 and 2 domains, interleukin-22 (IL22), and IL22 receptor alpha 1, were investigated for single nucleotide polymorphisms (SNPs) in Holstein bulls.
23	21328101	These SNPs, along with SNPs previously identified in IL10, IL10 receptor, and transforming growth factor beta 1 (TGFB1) genes, were evaluated for statistical associations to estimated breeding values for milk somatic cell score (SCS), a trait highly correlated to mastitis incidence, and various production-related traits, including milk yield, protein yield, fat yield, and lactation persistency.
24	21328101	While no significant associations were found between these SNPs and SCS, SNPs in IL10 receptor beta subunit showed a significant effect on protein yield and lactation persistency.
25	21328101	While there is evidence that IL10 plays an important role during lactation, it is also likely that the effects of SNPs in IL10 receptor beta subunit on protein yield and lactation persistency are due to linkage disequilibrium with a neighboring QTL.
26	21516112	Here we report that interleukin 23 (IL-23) and the transcription factor RORγt drove expression of the cytokine GM-CSF in helper T cells, whereas IL-12, interferon-γ (IFN-γ) and IL-27 acted as negative regulators.
27	21516112	Autoreactive helper T cells specifically lacking GM-CSF failed to initiate neuroinflammation despite expression of IL-17A or IFN-γ, whereas GM-CSF secretion by Ifng(-/-)Il17a(-/-) helper T cells was sufficient to induce experimental autoimmune encephalomyelitis (EAE).
28	21597988	Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status.
29	21597988	Twenty previously reported polymorphisms in genes encoding bovine interferon gamma (IFNG), IFNGR1, IFNGR2, IL22, IL22RA1, IL12RB1, IL12RB2, and IL23R were genotyped in a resource population of 446 dairy Holsteins with known MAP infection status, and logistic regression was used to assess the statistical association with a binomial MAP infection status phenotype.
30	21597988	Four SNPs in IFNGR2, IL12RB1, IL12RB2, and IL23R were found to be associated with the MAP infection status of the resource population.
31	22621183	Intracellular expression of IL-31, IFN-γ, IL-13, IL-17 and IL-22 was measured using flow cytometry.
32	22621183	Many IL-31-producing T cells co-produced IL-13 and to lesser extent IL-22, but rarely IFN-γ or IL-17.
33	22621183	Intracellular expression of IL-31, IFN-γ, IL-13, IL-17 and IL-22 was measured using flow cytometry.
34	22621183	Many IL-31-producing T cells co-produced IL-13 and to lesser extent IL-22, but rarely IFN-γ or IL-17.
35	22875907	CD3E (CD3)-IL2RB (CD122)+DBA cells were identified as the dominant Ifng transcript source.
36	22875907	In contrast, CD3E-IL2RB+DBA+ uNK cells expressed genes compatible with significantly greater potential for IL22 synthesis, angiogenesis, and participation in regulation mediated by the renin-angiotensin system (RAS).
37	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
38	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
39	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
40	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
41	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
42	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
43	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
44	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
45	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
46	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
47	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
48	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
49	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
50	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
51	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
52	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
53	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
54	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
55	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
56	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
57	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
58	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
59	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
60	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
61	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
62	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
63	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
64	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
65	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
66	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
67	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
68	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
69	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
70	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
71	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
72	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
73	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
74	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
75	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
76	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
77	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
78	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
79	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
80	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
81	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
82	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
83	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
84	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
85	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
86	23668260	The infected mice displayed a significant up-regulation in the expression of chemokines (Cxcl1, Cxcl2 and Ccl2), numerous pro-inflammatory cytokines (Ifng, Il1b, Il6, and Il17f), as well as Il22 and a number of anti-microbial peptides (Defa1, Defa28, Defb1, Slpi and Reg3g) at the site(s) of infection.
87	23668260	However, CD4 T cells of the untreated and C. difficile-infected mice expressed similar levels of CD69 and CD25.
88	23668260	Neither tissue had up-regulated levels of Tbx21, Gata3 or Rorc.
89	23668260	They also displayed significantly higher phosphorylation of AKT and signal transducer and activator of transcription 3 (STAT3), an indication of pro-survival signalling.
90	23668260	These data underscore the local, innate, pro-inflammatory nature of the response to C. difficile and highlight eIF2α phosphorylation and the interleukin-22-pSTAT3-RegIIIγ axis as two of the pathways that could be used to contain and counteract the damage inflicted on the intestinal epithelium.
91	23808390	Interleukin-26 (IL26) is a member of the IL10 cytokine family.
92	23808390	The IL26 gene is located between two other well-known cytokines genes of this family encoding interferon-gamma (IFNG) and IL22 in an evolutionary conserved gene cluster.
93	23850722	In the gene loci of IFN-γ, DYRK2, IL22, IL26 and MDM1 are found with conserved synteny in vertebrates, and similar genes adjacent to IFN-γR1 and IFN-γR2 were also found.
94	24164838	IL-22+ CD4+ T cells in patients with rheumatoid arthritis.