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Gene Information
Gene symbol: IL27
Gene name: interleukin 27
HGNC ID: 19157
Synonyms: IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM33 | 1 hits |
| 2 | C19orf10 | 1 hits |
| 3 | IFNA13 | 1 hits |
| 4 | IFNAR2 | 1 hits |
| 5 | IL12A | 1 hits |
| 6 | IL17D | 1 hits |
| 7 | NFKBIA | 1 hits |
| 8 | STAT2 | 1 hits |
| 9 | TGFBR1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19258923 | We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children. |
| 2 | 23464355 | Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types. |
| 3 | 23464355 | We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults. |
| 4 | 23464355 | We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice. |
| 5 | 23464355 | Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice. |
| 6 | 23464355 | Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication. |
| 7 | 23464355 | Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes. |
| 8 | 23464355 | This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations. |