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Gene Information
Gene symbol: IRF6
Gene name: interferon regulatory factor 6
HGNC ID: 6121
Synonyms: OFC6, VWS1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CXCL10 | 1 hits |
| 2 | CXCL5 | 1 hits |
| 3 | FCN1 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IFNGR1 | 1 hits |
| 6 | IFNGR2 | 1 hits |
| 7 | IRF2 | 1 hits |
| 8 | IRF3 | 1 hits |
| 9 | IRF4 | 1 hits |
| 10 | IRF8 | 1 hits |
| 11 | PID1 | 1 hits |
| 12 | PRKCDBP | 1 hits |
| 13 | TNFAIP6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8486096 | Administration of human gamma interferon (Hu-IFNg) at concentrations from 0.5 to 500 Units/ml produced a dose-related reversal of TCDD-induced suppression of in vitro antibody responses to both the polyclonal B cell activator, LPS, and the T-dependent antigen, sRBC in whole splenocytes isolated from female B6C3F1 mice. |
| 2 | 12517723 | A reduced capacity to produce this cytokine in the elderly, as demonstrated by our findings of significant decreases in IFN-gamma production in vitro on stimulation with bacterial products (LPS) or viral antigens (influenza vaccine), might therefore contribute to disease susceptibility. |
| 3 | 12517723 | Using tetramer technology and IFN-gamma ELISPOT assays, we found that the commonly-observed clonal expansions of CD8+ T-cells in the elderly were for the most part poorly-functional CMV- and EBV-specific cells, expressing little CD28. |
| 4 | 21859832 | In this study we examine genetic variation in IFNG, IFNGR1, IFNGR2 and interferon regulatory factors (IRFs) to determine associations with colon and rectal cancer and survival after diagnosis. |
| 5 | 21859832 | Five tagSNPs in IFNG, IRF2 and IRF3 were associated with colon cancer and eight tagSNPs in IFNGR1, IFNGR2, IRF2, IRF4, IRF6 and IRF8 were associated with rectal cancer. |
| 6 | 21859832 | IRF3 rs2304204 was associated with the strongest direct association and IRF2 3775554 with the strongest inverse association for colon cancer [odds ratios (ORs) 1.43, 95% confidence interval (CI) 1.12-1.82 for recessive model and 0.52, 95% CI 0.28-0.97 for unrestricted model]. |
| 7 | 21859832 | For rectal cancer, IFNGR1 rs3799488 was directly associated with risk (OR 2.30, 95% CI 1.04-5.09 for recessive model), whereas IRF6 rs861020 was inversely associated with risk (OR 0.57, 95% CI 0.34-0.95). |
| 8 | 21859832 | In this study we examine genetic variation in IFNG, IFNGR1, IFNGR2 and interferon regulatory factors (IRFs) to determine associations with colon and rectal cancer and survival after diagnosis. |
| 9 | 21859832 | Five tagSNPs in IFNG, IRF2 and IRF3 were associated with colon cancer and eight tagSNPs in IFNGR1, IFNGR2, IRF2, IRF4, IRF6 and IRF8 were associated with rectal cancer. |
| 10 | 21859832 | IRF3 rs2304204 was associated with the strongest direct association and IRF2 3775554 with the strongest inverse association for colon cancer [odds ratios (ORs) 1.43, 95% confidence interval (CI) 1.12-1.82 for recessive model and 0.52, 95% CI 0.28-0.97 for unrestricted model]. |
| 11 | 21859832 | For rectal cancer, IFNGR1 rs3799488 was directly associated with risk (OR 2.30, 95% CI 1.04-5.09 for recessive model), whereas IRF6 rs861020 was inversely associated with risk (OR 0.57, 95% CI 0.34-0.95). |
| 12 | 23874546 | Of these transcripts, six (TNFAIP6, FCN1, CXCL10, GBP1, CXCL5 and PID1) were differentially expressed in septic patients' blood compared to healthy blood upon ex vivo LPS stimulation and were restored by IFN-γ. |
| 13 | 23874546 | Along with the previously identified markers TNFa, IL10 and HLA-DRA, the potential value of these markers should now be evaluated in a larger cohort of patients. |