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Gene Information
Gene symbol: LAT
Gene name: linker for activation of T cells
HGNC ID: 18874
Synonyms: LAT1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD38 | 1 hits |
| 2 | CSF2 | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | IL10 | 1 hits |
| 5 | IL2 | 1 hits |
| 6 | IL4 | 1 hits |
| 7 | IL5 | 1 hits |
| 8 | PECAM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11259373 | Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway. |
| 2 | 11259373 | Results are as follows: 1) LP T cells express an enzymatically active form of CD38, characterized by a modified ratio between cyclase and hydrolase functions; 2) LP T cells do not mobilize Ca2+ upon CD38 ligation, as seen in PB T cells (this condition is due to a lack in activation of PLC- g, constantly observed in PB T lymphocytes); 3) The early steps of CD38 signaling involve activation of lck, syk, and LAT; 4) Late events include synthesis and release of IL-2, IL-4, IL-5, IL-10, IFN-g and GM-CSF; 5) The uniqueness of the CD38 pathway in LP T cells is not caused by impaired interactions with the CD31 ligand. |