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Gene Information
Gene symbol: LIF
Gene name: leukemia inhibitory factor
HGNC ID: 6596
Synonyms: CDF, DIA, HILDA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CNTF | 1 hits |
| 2 | CSF2 | 1 hits |
| 3 | CSF3 | 1 hits |
| 4 | IFNA2 | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | IL10 | 1 hits |
| 7 | IL11 | 1 hits |
| 8 | IL12A | 1 hits |
| 9 | IL1B | 1 hits |
| 10 | IL3 | 1 hits |
| 11 | IL6 | 1 hits |
| 12 | IL8 | 1 hits |
| 13 | SOCS1 | 1 hits |
| 14 | SOCS3 | 1 hits |
| 15 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7683736 | The differentiation inducing effects of interleukins (IL-1 beta, IL-3 and IL-6), colony stimulating factors (GCSF and GMCSF), TNF, LIF and IFNg, were studied either individually or in combination. |
| 2 | 7683736 | IL-3, IL-6, interferon gamma, GCSF and to a smaller extent IL-1 beta and GMCSF synergized the differentiation inducing activity of TNF. |
| 3 | 15145618 | Treatment with interferon-gamma (IFN-g) induced SOCS-1 and enhanced SOCS-3 expression, and was associated with decreased tumor necrosis factor-alpha (TNF) and increased leukemia inhibitory factor (LIF) in culture supernatants. |
| 4 | 15145618 | Treatment with conditioned medium from myelin basic protein-stimulated encephalitogenic lymphoid cells (MBP-CM) increased SOCS-3 and induced SOCS-1 expression. |
| 5 | 16373362 | Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance. |
| 6 | 16373362 | SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively. |
| 7 | 16373362 | To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease. |
| 8 | 16373362 | SOCS-1 and SOCS-3 were elevated throughout active disease in both strains. |
| 9 | 16373362 | At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords. |
| 10 | 16373362 | This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease. |
| 11 | 16373362 | SOCS-3 inducers in the IL-6 family were expressed differentially between the strains. |
| 12 | 16373362 | IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease. |
| 13 | 24204576 | Samples were analysed by immunofluorescence to identify the presence and abundance of B-B7 (B-cells), CD4 (LTh), CD8 (LTc), γδT cell receptor (TCR) and CD335/NKp46 (NK cells) -positive immune cells. |
| 14 | 24204576 | Quantitative real time PCR (QPCR) was carried out to analyse mRNA relative abundance of FOXP3 (a marker of regulatory T (Treg) cells) and a panel of immune factors, including MHC-I, LIF, Interleukins 1, 2, 6, 8, 10, 11,12A, IFNa and IFNG. |
| 15 | 24204576 | Results indicate that B-B7+ cells are quite populous in bovine endometrial tissue, CD4+ and CD8+ -cells are present in moderate numbers and γδTCR+ and CD335+ cells are present in low numbers. |
| 16 | 24204576 | Neither B lymphocytes nor T lymphocyte subsets were regulated temporally during the oestrous cycle or by pregnancy prior to implantation. mRNA transcript abundance of the immune factors LIF, IL1b, IL8 and IL12A, IFNa and IFNG, expression was regulated temporally during the estrous cycle and LIF, IL1b, IL-10, IL11, IL12A were also temporally regulated during pregnancy. |