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Gene Information
Gene symbol: RAP1B
Gene name: RAP1B, member of RAS oncogene family
HGNC ID: 9857
Synonyms: K-REV, RAL1B, DKFZp586H0723
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDK4 | 1 hits |
| 2 | DDIT3 | 1 hits |
| 3 | GLI1 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | LRP1 | 1 hits |
| 6 | MDM2 | 1 hits |
| 7 | TSPAN31 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8912848 | Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. |
| 2 | 8912848 | The genes most frequently amplified and overexpressed were CDK4 (with coamplification of SAS) and MDM2. |
| 3 | 8912848 | Because individual malignant gliomas showed CDK4/SAS amplification but no MDM2 amplification and vice versa, the possibility remained of a common amplification target gene located between CDK4 and MDM2. |
| 4 | 8912848 | All tumors and cell lines were analyzed at eight gene loci and six anonymous loci from 12q13-q15, including seven loci located between CDK4 and MDM2. |
| 5 | 8912848 | These studies revealed two centers of amplification, one at CDK4/SAS and the other at MDM2. |
| 6 | 8912848 | A number of loci located close to either MDM2 or CDK4/SAS, including the genes GADD153, GLI, RAP1B, A2MR, and IFNG, were found to be coamplified in some tumors but not overexpressed consistently. |
| 7 | 8912848 | All amplicons were discontinuous between CDK4/SAS and MDM2. |
| 8 | 8912848 | Our results thus exclude a common amplification target between CDK4/SAS and MDM2 and provide additional evidence that these genes represent two independent targets of selection. |