Ignet

Gene Information

Gene symbol: SOCS3

Gene name: suppressor of cytokine signaling 3

HGNC ID: 19391

Synonyms: SSI-3, CIS3, SOCS-3, Cish3

Related Genes

#	Gene Symbol	Number of hits
1	CISH	1 hits
2	IFNG	1 hits
3	IL6	1 hits
4	LIF	1 hits
5	MBP	1 hits
6	SOCS1	1 hits
7	TBX21	1 hits
8	TCF7	1 hits
9	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	15145618	Treatment with interferon-gamma (IFN-g) induced SOCS-1 and enhanced SOCS-3 expression, and was associated with decreased tumor necrosis factor-alpha (TNF) and increased leukemia inhibitory factor (LIF) in culture supernatants.
2	15145618	Treatment with conditioned medium from myelin basic protein-stimulated encephalitogenic lymphoid cells (MBP-CM) increased SOCS-3 and induced SOCS-1 expression.
3	15145618	Treatment with interferon-gamma (IFN-g) induced SOCS-1 and enhanced SOCS-3 expression, and was associated with decreased tumor necrosis factor-alpha (TNF) and increased leukemia inhibitory factor (LIF) in culture supernatants.
4	15145618	Treatment with conditioned medium from myelin basic protein-stimulated encephalitogenic lymphoid cells (MBP-CM) increased SOCS-3 and induced SOCS-1 expression.
5	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
6	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
7	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
8	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
9	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
10	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
11	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
12	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
13	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
14	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
15	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
16	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
17	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
18	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
19	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
20	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
21	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
22	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
23	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
24	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
25	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
26	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
27	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
28	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
29	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
30	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
31	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
32	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
33	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
34	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
35	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
36	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
37	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
38	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
39	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
40	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
41	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
42	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
43	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
44	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
45	16373362	Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 are members of a family of inducible intracellular proteins that negatively regulate cytokine signaling in cells of hematopoietic origin and may influence the Th1 to Th2 balance.
46	16373362	SOCS-1 and SOCS-3 are induced by cytokines that are known to be up-regulated during EAE, including IFN-gamma (IFN-g) and IL-6, respectively.
47	16373362	To test the hypothesis that the level of induction of SOCS-1 and SOCS-3 correlates with the course of EAE, mRNA levels were compared in spinal cords of SJL and B6 mice during discrete stages of disease.
48	16373362	SOCS-1 and SOCS-3 were elevated throughout active disease in both strains.
49	16373362	At peak EAE, SOCS-1 was higher and SOCS-3 was lower in B6 cords compared with SJL cords.
50	16373362	This correlated with greater expression of the Th1 cytokine, IFN-g, and less of the Th2 cytokine, IL-10, in B6 cords relative to SJL cords during onset and peak disease.
51	16373362	SOCS-3 inducers in the IL-6 family were expressed differentially between the strains.
52	16373362	IL-6 and leukemia inhibitory factor were higher at onset in B6 cords whereas ciliary neurotrophic factor was increased in SJL cords during peak disease.
53	21518797	The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns.
54	21518797	The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype.
55	21518797	In this study, we first identify Socs1, Socs3, and Tcf7 (TCF-1) as gene targets that are negatively regulated by T-bet.
56	21518797	Consistent with this, we identified two T-bet DNA-binding elements in the Socs1 promoter that are functionally used to down-regulate transcription in primary Th1 cells.
57	21518797	Furthermore, T-bet functionally recruits Bcl-6 to the Ifng locus in late stages of Th1 differentiation to repress its activity, possibly to prevent the overproduction of IFN-γ, which could result in autoimmunity.