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Gene Information
Gene symbol: TLR4
Gene name: toll-like receptor 4
HGNC ID: 11850
Synonyms: hToll, CD284, TLR-4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | IL10 | 1 hits |
| 3 | IL12A | 1 hits |
| 4 | IL18 | 1 hits |
| 5 | IL1B | 1 hits |
| 6 | JUN | 1 hits |
| 7 | NFKB1 | 1 hits |
| 8 | SLC11A1 | 1 hits |
| 9 | STAT1 | 1 hits |
| 10 | STAT4 | 1 hits |
| 11 | STAT6 | 1 hits |
| 12 | TLR1 | 1 hits |
| 13 | TLR2 | 1 hits |
| 14 | TLR6 | 1 hits |
| 15 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18062835 | Single nucleotide polymorphisms (SNPs) in the TLR4 (rs4986790), IFNG (rs2430561 and rs1861493), STAT1 (rs1914408), IL1B (rs16944), NRAMP (SLC11A1 rs2276631), JUN (rs11688) and VDR (rs10735810) genes were determined. |
| 2 | 18345012 | Fibrous tissue formation is regulated by the balance between plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (tPA), which reciprocally regulate fibrin deposition. |
| 3 | 18345012 | Adhesion development depended upon the interferon-gamma (IFN-gamma) and signal transducer and activator of transcription-1 (STAT1) system. |
| 4 | 18345012 | This response does not depend on STAT4, STAT6, interleukin-12 (IL-12), IL-18, tumor necrosis factor-alpha, Toll-like receptor 4 or myeloid differentiation factor-88-mediated signals. |
| 5 | 18345012 | Wild-type mice increased the ratio of PAI-1 to tPA after cecal cauterization, whereas Ifng(-/-) or Stat1(-/-) mice did not, suggesting that IFN-gamma has a crucial role in the differential regulation of PAI-1 and tPA. |
| 6 | 18345012 | Additionally, hepatocyte growth factor, a potent mitogenic factor for hepatocytes, strongly inhibited intestinal adhesion by diminishing IFN-gamma production, providing a potential new way to prevent postoperative adhesions. |
| 7 | 19007808 | In this study, we demonstrate distinct expression patterns of innate immune genes including - Toll-like receptors (TLRs) (TLR2, TLR15 and TLR21, but not TLR4), the complete repertoire of AvBDs, CTHLs and both pro- and anti-inflammatory cytokines (IL1B, IL8, IFNG and IL10) during early chicken embryonic development. |
| 8 | 19233457 | TLR4, transcription factor NFKB1 and the inflammatory cytokines IFNG, IL1A, IL6, IL8, IL12A were all significantly increased in EPP cows (P<0.05). |
| 9 | 19233457 | Increase in HP, SAA3, TAP and DEFB5 genes was particularly marked in cows with severe inflammation. |
| 10 | 20093719 | It has been defined that mast cells express TLR2, TLR4, TLR1 and TLR6. |
| 11 | 20093719 | There is also some data proving that mast cells possess TLR5, TLR3 and TLR9 molecules. |
| 12 | 20093719 | The presence of TLR7, TLR9, and TLR10 on mast cells is still unclear. |
| 13 | 20093719 | Some data indicate that TLR expression by mast cells can be modulated by various cytokines, such as granulocyte-macrophage colony stimulating factor (GM-CSF) and interferon (IFN)-g, cathelicidin LL-37 as well as by some bacterial components. |