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Gene Information
Gene symbol: ADAMTS13
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif, 13
HGNC ID: 1366
Synonyms: VWFCP, TTP, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | VWF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21252531 | TTP can be inherited due to deficiencies in the activity of von Willebrand factor cleaving protease (ADAMTS13) or acquired due to the presence of autoantibodies directed against ADAMTS13. |
| 2 | 22966172 | In thrombotic thrombocytopenic purpura, the clinical impact of ADAMTS13 deficiency caused by autoantibodies likely depends on the balance between residual antigen, that is, enzyme activity, and demand imposed by local genesis of ultralarge multimers of von Willebrand factor. |
| 3 | 22966172 | A corollary of these concepts is that disrupting platelet factor 4 and β(2)GPI conformation (or ultralarge multimer of von Willebrand factor oligomerization or function) might provide a disease-targeted approach to prevent thrombosis without systemic anticoagulation or immunosuppression. |