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Gene Information
Gene symbol: ADCY1
Gene name: adenylate cyclase 1 (brain)
HGNC ID: 232
Synonyms: AC1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL10 | 1 hits |
| 2 | IL1B | 1 hits |
| 3 | IL6 | 1 hits |
| 4 | PRKAR2A | 1 hits |
| 5 | PRKCA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8964084 | CT induced production of immunostimulating (IL-1 beta and IL-6) and immunosuppressive (IL-10) cytokines by PBMC. |
| 2 | 8964084 | However, the dose-response curve of its cytokine-inducing activity did not correlate well with the concentrations of intracellular cAMP generated by varying doses of CT. the CT mode of action on human PBMC, regarding induction of these cytokines, was clarified by the use of inhibitors of adenyl cyclase, protein kinase A (PKA), and protein kinase C (PKC). 2',3'-Dideoxyadenosine, which inhibits adenyl cyclase activity, reduced IL-1, IL-6, and IL-10 levels by 29, 15, and 28% respectively. |
| 3 | 8964084 | HA1004, an inhibitor of PKA, reduced the IL-1 and IL-6 levels by 29 and 27%, respectively. |