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Gene Information
Gene symbol: ADORA3
Gene name: adenosine A3 receptor
HGNC ID: 268
Synonyms: AD026
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL6 | 1 hits |
| 2 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16849509 | Remarkably, newborn blood plasma confers substantially reduced BLP-induced monocyte synthesis of TNF-alpha, while preserving IL-6 synthesis, reflecting the presence in neonatal blood plasma of a soluble, low molecular mass inhibitory factor (<10 kDa) that we identify as adenosine, an endogenous purine metabolite with immunomodulatory properties. |
| 2 | 16849509 | Selective inhibition of neonatal TNF-alpha production is due to the distinct neonatal adenosine system, including relatively high adenosine concentrations in neonatal blood plasma and heightened sensitivity of neonatal mononuclear cells to adenosine A3 receptor-mediated accumulation of cAMP, a second messenger that inhibits TLR-mediated TNF-alpha synthesis but preserves IL-6 production. |