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Gene Information
Gene symbol: AIFM1
Gene name: apoptosis-inducing factor, mitochondrion-associated, 1
HGNC ID: 8768
Synonyms: AIF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AIF1 | 1 hits |
| 2 | AIFM3 | 1 hits |
| 3 | BAX | 1 hits |
| 4 | BCL2 | 1 hits |
| 5 | CASP3 | 1 hits |
| 6 | CASP8 | 1 hits |
| 7 | CASP9 | 1 hits |
| 8 | CYCS | 1 hits |
| 9 | MIPEP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12140745 | Apoptosis was associated with depolarization of mitochondrial membrane, release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria, and activation of caspase-9 and caspase-3, but not of caspase-8. |
| 2 | 12140745 | In addition, thimerosal in a concentration-dependent manner inhibited the expression of XIAP, cIAP-1 but did not influence cIAP-2 expression. |
| 3 | 12140745 | Finally, exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3. |
| 4 | 15033799 | Bcl-2 overproduction in Jurkat T cells (Jurkat-Bcl-2) abolished both caspase activation and AIF distribution. |
| 5 | 21347304 | It is demonstrated that the MIP cell-free supernatant induced apoptosis is mitochondria-mediated and caspase independent and involves mitochondrial translocation of Bax and subsequent release of AIF and cytochrome c from the mitochondria. |
| 6 | 26455649 | There are three isozymes of AIF that have been identified to date, designated as AIF1, AIF2, and AIF3; the human AIF3 is also known as an AIF-like protein (AIFL). |