Ignet

Gene Information

Gene symbol: ALPP

Gene name: alkaline phosphatase, placental

HGNC ID: 439

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	ALPI	1 hits
3	CTLA4	1 hits
4	FASLG	1 hits
5	G6PD	1 hits
6	GPI	1 hits
7	GPT	1 hits
8	IFNG	1 hits
9	IL12A	1 hits
10	IL12B	1 hits
11	IL2	1 hits
12	ME1	1 hits
13	NAGLU	1 hits
14	NPM1	1 hits
15	PPP1R3C	1 hits
16	PRL	1 hits
17	PTH	1 hits
18	SDHB	1 hits
19	SLC17A5	1 hits
20	SORD	1 hits
21	TNF	1 hits
22	TP63	1 hits

Related Sentences

#	PMID	Sentence
1	2180798	An enzyme immunoassay (EIA) and an enzyme-linked immunosorbent assay (ELISA) were developed with alkaline phosphatase (ALP) as a label enzyme.
2	7258783	Infection with the virulent isolates produced severe anemia (mean RBC count = about 2 million/mm3) and caused increases in serum total bilirubin (TBILI), direct bilirubin (DBILI), serum urea nitrogen (SUN), alkaline phosphatase (ALP), and serum aspartate aminotransferase (AST) that were significantly higher than comparable changes in control values.
3	7258783	Marked increase in TBILI, DBILI, SUN, ALP, and AST were detected 0 to 1 day before death in 3 cows.
4	7258783	Infection with the virulent isolates produced severe anemia (mean RBC count = about 2 million/mm3) and caused increases in serum total bilirubin (TBILI), direct bilirubin (DBILI), serum urea nitrogen (SUN), alkaline phosphatase (ALP), and serum aspartate aminotransferase (AST) that were significantly higher than comparable changes in control values.
5	7258783	Marked increase in TBILI, DBILI, SUN, ALP, and AST were detected 0 to 1 day before death in 3 cows.
6	7569773	Changes in biological activities could be followed by employing enzymes (glucose-6-phosphate dehydrogenase and human placental alkaline phosphatase) as antigens.
7	9477478	Average daily gains (ADG), alkaline phosphatase (ALP) activity, cholesterol concentrations, rectal temperatures, and serum prolactin concentrations were measured to confirm fescue toxicosis in steers grazing EI fescue.
8	9780825	Enzymatic changes (increases in AST, alanine aminotransferase (ALT) and lactic dehydrogenase (LDH) and decreases in sorbitol dehydrogenase (SDH), alkaline phosphatase (ALP) and malic enzyme (MEZ)), decreases in total proteins and albumin, and increases in urea and creatinine might reflect the degree of severity of the damage to the liver and kidney tissues.
9	15655551	Using cultured T cells, 'exosomes' were evaluated for suppression of CD3-zeta and JAK 3 expressions and induction of apoptosis, measured by DNA fragmentation.
10	15655551	'Exosomes' expressed class I MHC, placental alkaline phosphatase, B23/nucleophosmin, and FasL.
11	15655551	'Exosomes' suppressed expression of T-cell activation signalling components, CD3-zeta and JAK 3 and induced apoptosis.
12	16339569	Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma.
13	16339569	In primary osteoblasts cultured in Th2 cell condition medium, the alkaline phosphatase (ALP) activity was maintained at a basal level.
14	16339569	However, antagonizing PTH in the condition medium resulted in a significant reduction of the ALP activity.
15	16339569	Conversely, treatment of osteoblasts with IFN-gamma suppressed the ALP activity.
16	16339569	In addition, the Th2 cytokine environment also regulated to expression of receptor activator of NF-kappaB ligand and osteoprotegerin through both PTH-dependent and -independent mechanisms.
17	16339569	Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma.
18	16339569	In primary osteoblasts cultured in Th2 cell condition medium, the alkaline phosphatase (ALP) activity was maintained at a basal level.
19	16339569	However, antagonizing PTH in the condition medium resulted in a significant reduction of the ALP activity.
20	16339569	Conversely, treatment of osteoblasts with IFN-gamma suppressed the ALP activity.
21	16339569	In addition, the Th2 cytokine environment also regulated to expression of receptor activator of NF-kappaB ligand and osteoprotegerin through both PTH-dependent and -independent mechanisms.
22	16339569	Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma.
23	16339569	In primary osteoblasts cultured in Th2 cell condition medium, the alkaline phosphatase (ALP) activity was maintained at a basal level.
24	16339569	However, antagonizing PTH in the condition medium resulted in a significant reduction of the ALP activity.
25	16339569	Conversely, treatment of osteoblasts with IFN-gamma suppressed the ALP activity.
26	16339569	In addition, the Th2 cytokine environment also regulated to expression of receptor activator of NF-kappaB ligand and osteoprotegerin through both PTH-dependent and -independent mechanisms.
27	16928134	We have attempted to identify T-cell epitopes suitable for the development of a peptide-based cancer vaccine directed towards placental isozyme of alkaline phosphatase (PLAP), an oncofetal antigen.
28	17219949	Then a 23 amino-acid signal peptide of human interleukin-2 (IL-2) upstream Sj14 or Sj26 gene and a membrane-anchored sequence containing 32 amino-acids of carboxyl-terminal of human placental alkaline phosphatase (PLAP) downstream were amplified by PCR as the template of plasmid pVAC-Sj14 or pVAC-Sj26 only to get two gene fragments including Sj14 gene and Sj26 gene.
29	17828746	Safety studies were carried out by measuring the levels of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and tumor necrosis factor alpha (TNF-alpha) in bronchoalveolar lavage (BAL) fluid.
30	19277872	THP-1 cells were exposed to these MPs for 24 h and characteristics of cell morphology, tumor necrosis factor-alpha (TNF-alpha) release, lactate dehydrogenase (LDH), N-acetyl-beta-D: -glucosaminidase (NAG) and alkaline phosphatase (ALP) activity in AMPhi culture supernatants were measured.
31	19956842	A mammalian co-expression plasmid of glycolipid-anchored-IL-12 (GPI-IL-12) was constructed by subcloning IL-12A chain gene (P35 subunit) and a fusion gene containing GPI-anchor signal sequence of human placental alkaline phosphatase-1 (hPLAP-1) and IL-12B chain gene (P40 subunit) in pBudCE4.1.
32	19956842	The incorporation of GPI-IL-12 onto exosomes (exosomes-GPI-IL-12, EXO/IL-12) significantly promotes proliferation of T cells, and subsequently increased the release of IFN-gamma.
33	23765772	Both the CDT and logistic regression modeling demonstrated the importance of the routine pathology variables alanine aminotransferase (ALT), serum albumin (ALB), and alkaline phosphatase (ALP) to accurately predict HBsAg status in a Chinese patient cohort.
34	24041689	Co-stimulatory signaling pathway triggered by the binding of B7.1/B7.2 (CD80/86) of antigen-presenting cells (APCs) to CD28 of T cells is required for optimal T-cell activation.
35	24041689	Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding with a greater affinity.
36	24041689	To develop a novel therapeutics specifically targeting CTLA-4, we constructed a DNA vaccine by cloning the sequence of CTLA-4 fused with a transmembrane domain sequence of placental alkaline phosphatase (PLAP) into a mammalian expression plasmid, pVAC-1.