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PMID |
Sentence |
1 |
21308386
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We characterized the prevalence of pilus islets 1 (PI-1) and 2 (PI-2) and the clonality of Streptococcus pneumoniae isolates taken from children with acute otitis media (AOM) to study the association between pilus existence and AOM disease potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance.
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2 |
21308386
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Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal PI-1 and PI-2 genes.
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3 |
21308386
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The importance of PI-1 in AOM infections and its association with the spread of antimicrobial resistance requires further research.
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4 |
22495112
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There were 301 Spn NP colonization episodes documented in 109 (65%) children and 42 Spn AOM episodes in 34 (20%) children.
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5 |
22495112
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IgG antibody titers to the 5 proteins were significantly different among children over time (p < 0.001), with a rank order as follows: PcpA > PhtE = PhtD > Ply > LytB Characterization of IgG and IgM acute and convalescent serum antibody levels of Spn AOM infection showed the kinetics of the response differed among children, with the same rank order of antibody levels over time.
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6 |
22495112
|
There were 301 Spn NP colonization episodes documented in 109 (65%) children and 42 Spn AOM episodes in 34 (20%) children.
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7 |
22495112
|
IgG antibody titers to the 5 proteins were significantly different among children over time (p < 0.001), with a rank order as follows: PcpA > PhtE = PhtD > Ply > LytB Characterization of IgG and IgM acute and convalescent serum antibody levels of Spn AOM infection showed the kinetics of the response differed among children, with the same rank order of antibody levels over time.
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8 |
23560785
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Potential coverage with PCV10 vaccine would be 46.5 % and 60.7 % for pneumococci involved in AOM and INV, respectively; it would be 71.7 % and 73 % with PCV13.
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9 |
24350587
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Serotype 19A was prevalent among AOM, CAP and nasopharyngeal isolates and among antibiotic resistant isolates in all age groups.
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10 |
25648056
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However, children with Spn AOM had 5-8-fold lower IgG and 3-6-fold lower IgA levels to the three proteins than children without AOM but asymptomatically colonized with Spn.
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