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Gene Information

Gene symbol: APCS

Gene name: amyloid P component, serum

HGNC ID: 584

Synonyms: SAP, PTX2, MGC88159

Related Genes

#	Gene Symbol	Number of hits
1	APLP2	1 hits
2	BACE1	1 hits
3	CAMP	1 hits
4	CRP	1 hits

Related Sentences

#	PMID	Sentence
1	3092598	Furthermore, levels of serum amyloid P component (SAP) were also determined.
2	8213351	Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation.
3	8213351	A simple and reliable animal model to quantify interleukin-1 (IL-1) production at a site of inflammation has been developed and characterised.
4	8213351	The local inflammatory reaction in the chamber, over a 30 day time course, was characterised by leucocyte infiltration, and marked increases in protein, prostaglandin E2, IL-1 and IL-6 concentrations in the chamber fluid.
5	8213351	A rapid increase in plasma concentrations of the acute-phase reactant serum amyloid P (SAP) also occurred.
6	12491773	These are beta-secretase inhibitors, gamma-secretase inhibitors, A beta degrading enzymes, anti-cholesterol drugs, non-steroidal anti-inflammatory drugs, beta-sheet breakers, chelating agents, SAP competitors, beta-amyloid vaccination, agents for trapping peripheral A beta, and so on.
7	12763682	Long pentraxins consist of a C-terminal pentraxin domain, which has sequence similarity to C-reactive protein (CRP) and serum amyloid P (SAP) component (the classic short pentraxins), and of an unrelated N-terminal portion.
8	12763682	PTX3 is made by diverse cell types, most prominently endothelial cells, macrophages and dendritic cells, in response to primary inflammatory signals (e.g. interleukin-1 (IL-1), tumour necrosis factor (TNF), lipopolysaccharide (LPS)).
9	21278351	We hypothesize that serum amyloid P component (SAP), which has a species-specific, DNA-binding ability, contributes to the differences between human and mice and then limits DNA vaccine's efficacy in vivo.
10	21278351	Using human promonocytic cell line THP-1-derived macrophages as a cell model, we found that cells incubated with a hSAP-DNA complex showed significant defects in innate immune activations, whereas mouse SAP had similar, albeit very weak, activities. hSAP also significantly inhibited the functions of two identified DNA sentinels, high-mobility group B protein 1 and antimicrobial peptide LL37, and redirected DNA update to FcRs leading to endocytosis and endosomal degradation.
11	21278351	We hypothesize that serum amyloid P component (SAP), which has a species-specific, DNA-binding ability, contributes to the differences between human and mice and then limits DNA vaccine's efficacy in vivo.
12	21278351	Using human promonocytic cell line THP-1-derived macrophages as a cell model, we found that cells incubated with a hSAP-DNA complex showed significant defects in innate immune activations, whereas mouse SAP had similar, albeit very weak, activities. hSAP also significantly inhibited the functions of two identified DNA sentinels, high-mobility group B protein 1 and antimicrobial peptide LL37, and redirected DNA update to FcRs leading to endocytosis and endosomal degradation.
13	21544098	Serum amyloid P component facilitates DNA clearance and inhibits plasmid transfection: implications for human DNA vaccine.
14	21544098	Using proteomics, we showed that human serum amyloid P component (hSAP) is specifically present in human DNA-protein complexes.
15	21544098	Serum amyloid P component facilitates DNA clearance and inhibits plasmid transfection: implications for human DNA vaccine.
16	21544098	Using proteomics, we showed that human serum amyloid P component (hSAP) is specifically present in human DNA-protein complexes.
17	22270715	The upregulation of gene encoding serum amyloid P component (prototypic mouse acute phase reactant) was detected in the liver and to a lesser degree in the tumor of vaccinated mice at 24 h post-PDT vaccine treatment.
18	26182985	Pentraxins are a family of evolutionary conserved proteins that contains two main members, namely c-reactive proteins (CRPs) and serum amyloid P (SAP), which are involved in acute phase responses in animals.