Ignet

Gene Information

Gene symbol: APOB

Gene name: apolipoprotein B (including Ag(x) antigen)

HGNC ID: 603

Related Genes

#	Gene Symbol	Number of hits
1	AGT	1 hits
2	APOBEC1	1 hits
3	APOE	1 hits
4	CD8A	1 hits
5	HSPD1	1 hits
6	LDLR	1 hits
7	LPAL2	1 hits
8	STN	1 hits

Related Sentences

#	PMID	Sentence
1	15193153	HepG2 cells and hyperlipidemic mice deficient in both the low density lipoprotein receptor and the apoB mRNA editing enzyme genes (LDLR-/-Apobec1-/-; LDb) were transduced with rAAV2-TTR-RB15 and a control vector rAAV-TTR-RB15-mutant (inactive ribozyme).
2	21550372	First, naïve human hepatoma Huh7 cells were grown in serum-free medium that was supplemented with human-derived insulin, transferrin and sodium selenite.
3	21550372	ApoB and ApoE antibody-depletion assays suggested that infection of serum-free cultured HCV was independent of ApoB and ApoE proteins.
4	23313656	In particular, the apolipoprotein B100 (ApoB100) and the cholesterilester transferase protein (CETP) have been targeted in these strategies.
5	23345063	In this study we immunised apolipoprotein E-deficient (apoE(-/-)) mice with apoB-100-derived peptides P2, P45 and P210.
6	23345063	We used enzyme-linked immunosorbent assays to assess the synthesis of anti-peptide-specific IgG1 and IgG2a as well as the levels of interleukin (IL-)10 and interferon gamma (IFN-γ) in plasma of immunised animals.
7	23345063	We also measured the effect of immunisation on the number of spleen-derived CD4(+) and CD8(+) regulatory T cells (Tregs) in these animals.
8	23653002	Isocitrate lyase encoding plasmids in BCG cause increased survival in ApoB100-only LDLR-/- mice.
9	23653002	ApoB100-only LDLR-/- (B6;129S-ApoBtm2SgyLdlrtm1Her/J) mice were inoculated with M. bovis BCG harbouring plasmids carrying the gene for isocitrate lyase.
10	23653002	Isocitrate lyase encoding plasmids in BCG cause increased survival in ApoB100-only LDLR-/- mice.
11	23653002	ApoB100-only LDLR-/- (B6;129S-ApoBtm2SgyLdlrtm1Her/J) mice were inoculated with M. bovis BCG harbouring plasmids carrying the gene for isocitrate lyase.
12	24962340	In the present study we expressed epitopes from apolipoprotein B 100 (ApoB), human heat shock protein (HSP60) and Chlamydia pneumonia outer membrane protein (Cpn) in a single protein scaffold and used this multi-antigenic construct to induce tolerance to individual peptides by oral route in ApoBtm2Sgy/Ldlrtm1Her/J mice.
13	24962340	CD11c+ cells coexpressing CD11b and CD103 increased in lymphoid organs and were found to activate regulatory T cells and reduce effector T-cell response.
14	25218904	We intend to discuss: i) how apoB is responsible for the deleterious effects of LDL in the development of ischemic cardiovascular disease; ii) why vaccine based on peptides derived from apoB-100 is a promising therapy for treating ischemic cardiovascular disease, and iii) direct inhibition of apoB production should be a better therapeutic option than simple LDL-cholesterol lowering therapy in the patients with severe hypercholesterolemia at high cardiovascular risk with statin intolerance.
15	25677313	ApoB-100-related peptide vaccine protects against angiotensin II-induced aortic aneurysm formation and rupture.
16	26121471	Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice.
17	26121471	We recently reported that immunization with apoB-100 related peptide, p210, modified CD8+ T cell function in angiotensin II (AngII)-infused apoE (-/-) mice.
18	26121471	In this study, we hypothesized that p210 vaccine modulates blood pressure in AngII-infused apoE (-/-) mice.
19	26121471	At euthanasia, inflammatory genes IL-6, TNF-α, and MCP-1 in renal tissue were down-regulated by p210 vaccine.
20	26121471	Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice.
21	26121471	We recently reported that immunization with apoB-100 related peptide, p210, modified CD8+ T cell function in angiotensin II (AngII)-infused apoE (-/-) mice.
22	26121471	In this study, we hypothesized that p210 vaccine modulates blood pressure in AngII-infused apoE (-/-) mice.
23	26121471	At euthanasia, inflammatory genes IL-6, TNF-α, and MCP-1 in renal tissue were down-regulated by p210 vaccine.