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Gene Information
Gene symbol: ARHGEF5
Gene name: Rho guanine nucleotide exchange factor (GEF) 5
HGNC ID: 13209
Synonyms: TIM, TIM1, GEF5, P60
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HAVCR2 | 1 hits |
| 2 | MUC1 | 1 hits |
| 3 | SND1 | 1 hits |
| 4 | TIMD4 | 1 hits |
| 5 | WDR48 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25009824 | Virulence of different intermediate derivatives of QY1 (P5, P60, P80, and P100) were determined. |
| 2 | 25009824 | Pathogenicity study showed that pigs inoculated with QY1 P100 and P80 did not develop any significant PRRS clinic symptoms. |
| 3 | 26211834 | Tim-3 and Tim-4 as the potential targets for antitumor therapy. |
| 4 | 26211834 | Both Tim-3 and Tim-4 belong to the T-cell immunoglobulin and mucin domain (Tim) gene family, which plays a critical role in immunoregulation. |
| 5 | 26211834 | Recently, data from experimental models of tumor discovered that Tim-3 and Tim-4 up-regulation on tumor associated dendritic cells and macrophages attenuated the anti-tumor effects of cancer vaccines and chemotherapy. |
| 6 | 26211834 | Moreover, co-blockage of Tim-3 and PD-1, Tim-3 and CD137, Tim-3 and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) could enhance cell-mediated immunity in advanced tumor, and combined treatment with anti-Tim-3 and anti-Tim-4 mAbs further increase the efficacy of cancer vaccines. |
| 7 | 26211834 | The therapeutic manipulation of TIM-3 and TIM-4 may provide a novel strategy to improve the clinical efficacy of cancer immunotherapy. |