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Gene Information
Gene symbol: ATF6
Gene name: activating transcription factor 6
HGNC ID: 791
Synonyms: ATF6A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF4 | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | CYCS | 1 hits |
| 4 | DAPK1 | 1 hits |
| 5 | DDIT3 | 1 hits |
| 6 | EIF2A | 1 hits |
| 7 | EIF2AK3 | 1 hits |
| 8 | EIF2S1 | 1 hits |
| 9 | ERN1 | 1 hits |
| 10 | HSPA5 | 1 hits |
| 11 | KRR1 | 1 hits |
| 12 | MAPK3 | 1 hits |
| 13 | RIPK1 | 1 hits |
| 14 | TNFAIP3 | 1 hits |
| 15 | XBP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17686866 | We evaluated the role of the three major UPR pathways, namely, inositol-requiring enzyme 1-dependent splicing of X box binding protein 1 (XBP1) mRNA, activation of activating transcription factor 6 (ATF6), and protein kinase R-like endoplasmic reticulum (ER) kinase-dependent eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation, in WNV-infected cells. |
| 2 | 17686866 | We further observed a transient phosphorylation of eIF2alpha and induction of the proapoptotic cyclic AMP response element-binding transcription factor homologous protein (CHOP). |
| 3 | 17686866 | WNV-infected cells exhibited a number of apoptotic phenotypes, such as (i) induction of growth arrest and DNA damage-inducible gene 34, (ii) activation of caspase-3, and (iii) cleavage of poly(ADP-ribose) polymerase. |
| 4 | 19258633 | Other branches of the UPR pathways controlled by IRE1 and ATF6 proteins, respectively, are not involved. 2. |
| 5 | 22699507 | An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. |
| 6 | 22699507 | The death-associated protein kinase 1 (DAPK1), an IFN-γ-induced enzyme, controls cell cycle, apoptosis, autophagy, and tumor metastasis, and its expression is frequently down-regulated in a number of human tumors. |
| 7 | 22699507 | Here, we show that ATF6, an ER stress-induced transcription factor, interacts with C/EBP-β in an IFN-stimulated manner and is obligatory for Dapk1 expression. |
| 8 | 22699507 | IFN-stimulated proteolytic processing of ATF6 and ERK1/2-mediated phosphorylation of C/EBP-β are necessary for these interactions. |
| 9 | 22699507 | An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. |
| 10 | 22699507 | The death-associated protein kinase 1 (DAPK1), an IFN-γ-induced enzyme, controls cell cycle, apoptosis, autophagy, and tumor metastasis, and its expression is frequently down-regulated in a number of human tumors. |
| 11 | 22699507 | Here, we show that ATF6, an ER stress-induced transcription factor, interacts with C/EBP-β in an IFN-stimulated manner and is obligatory for Dapk1 expression. |
| 12 | 22699507 | IFN-stimulated proteolytic processing of ATF6 and ERK1/2-mediated phosphorylation of C/EBP-β are necessary for these interactions. |
| 13 | 24114795 | UPR, a cellular response to accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen, is initiated by three ER-lumen-resident sensors (PERK, IRE1 and ATF6), and involves transcriptional and translational regulation of the expression of several genes. |
| 14 | 24959724 | Furthermore, HEV ORF3 regulated A20 primarily via activating transcription factor 6 (ATF6), involved in unfolded protein response (UPR), resulting in the degradation or inactivation of the receptor interacting protein 1 (RIP1), a major upstream activator of IKB kinase compounds (IKKs). |
| 15 | 25633898 | Finally, we discovered the over-expression of GRP78, ATF4, ATF6, PERK, eIF2α, CHOP, and cytochrome c (Cyt-c) but not IRE1, xbp-1, and caspase-3 in B.suis.S2 (HK)-attacked and B.suis.S2-infected cells, suggesting that the molecular mechanism of ER stress sensor activation by B.suis.S2 is basically concomitant with that by B.suis.S2 (HK) and that ER stress, especially the PERK pathway, plays an important role in the process of B.suis.S2 infecting EEC, which may, in part, explain the role of the uterus in the pathogenesis of B.suis.S2. |
| 16 | 26303456 | ISAV induce the main symptoms and signaling pathways of UPR (ATF6, PERK and IRE1) without inducing translational attenuation. |