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Gene Information
Gene symbol: ATG5
Gene name: autophagy related 5
HGNC ID: 589
Synonyms: ASP, APG5, hAPG5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATG2B | 1 hits |
| 2 | ATG3 | 1 hits |
| 3 | ATG7 | 1 hits |
| 4 | BECN1 | 1 hits |
| 5 | CASP3 | 1 hits |
| 6 | MAP1LC3A | 1 hits |
| 7 | PTPN11 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22361584 | We observed that the knockdown of essential autophagy-related genes (ATG3, ATG5, ATG7 and BECN1) abolishes the pre-apoptotic secretion of ATP by several human and murine cancer cell lines undergoing ICD. |
| 2 | 22361584 | Cancer cell lines stably depleted of ATG5 or ATG7 normally generate tumors in vivo, and such autophagy-deficient neoplasms, upon systemic treatment with ICD inducers, exhibit the same levels of apoptosis (as monitored by nuclear shrinkage and caspase-3 activation) and necrosis (as determined by following the kinetics of HMGB1 release) as their autophagy-proficient counterparts. |
| 3 | 22361584 | We observed that the knockdown of essential autophagy-related genes (ATG3, ATG5, ATG7 and BECN1) abolishes the pre-apoptotic secretion of ATP by several human and murine cancer cell lines undergoing ICD. |
| 4 | 22361584 | Cancer cell lines stably depleted of ATG5 or ATG7 normally generate tumors in vivo, and such autophagy-deficient neoplasms, upon systemic treatment with ICD inducers, exhibit the same levels of apoptosis (as monitored by nuclear shrinkage and caspase-3 activation) and necrosis (as determined by following the kinetics of HMGB1 release) as their autophagy-proficient counterparts. |
| 5 | 25046112 | Colocalization of NS1 and LC3 was also observed in Atg5 deficient MEFs, which contain only the nonlipidated form of LC3. |
| 6 | 25046112 | While silencing of ERAD regulators EDEM1 and SEL1L suppressed JEV replication, LC3 depletion exerted a profound inhibition with significantly reduced RNA levels and virus titers. |
| 7 | 25356988 | Single nucleotide polymorphisms (SNPs) in the autophagy genes ATG2B (rs3759601) and ATG5 (rs2245214) influenced both the in vitro and in vivo training effect of BCG upon restimulation with unrelated bacterial or fungal stimuli. |
| 8 | 25362489 | Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. |