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Gene Information
Gene symbol: B3GALTL
Gene name: beta 1,3-galactosyltransferase-like
HGNC ID: 20207
Synonyms: B3GTL, B3Glc-T
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABO | 1 hits |
| 2 | ACRV1 | 1 hits |
| 3 | ADRA1D | 1 hits |
| 4 | B3GALT6 | 1 hits |
| 5 | C1GALT1 | 1 hits |
| 6 | MGAT1 | 1 hits |
| 7 | MGAT2 | 1 hits |
| 8 | MUC1 | 1 hits |
| 9 | NEU1 | 1 hits |
| 10 | SPAM1 | 1 hits |
| 11 | SSFA2 | 1 hits |
| 12 | UAP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7529488 | Sequence homology was searched among the nine cDNAs/deduced amino acid sequences encoding for the eight fertilization-related sperm antigens: namely, lactate dehydrogenase (LDH-C4), galactosyltransferase (GT), SP-10, rabbit sperm autoantigen (RSA), guinea pig (g)PH-20, cleavage signal protein (CS-1), HSA-63, human (h)PH-20, and AgX-1, respectively. |
| 2 | 7529488 | Most significant identity (> 50%) was found between HSA-63 and SP-10 (59.8%), and between gPH-20 and hPH-20 (61.1%); followed by identity between SP-10 and GT (34.7%); and then between AgX-1 and hPH-20 (39.4%). |
| 3 | 11522233 | Incubation of leukemia or lymphoma cells with neuraminidase and recombinant alpha 1,3-galactosyltransferase results in the synthesis of many alpha-gal epitopes (Gal alpha 1-3Gal beta 1-4GlcNAc-R) on their cell membranes. |
| 4 | 16288048 | B16 melanoma vaccines genetically engineered to express alphaGal epitopes (B16alphaGal) effectively treated preexisting s.c. and pulmonary alphaGal-negative melanoma (B16Null) tumors in the alpha(1,3)-galactosyltransferase knockout mouse model. |
| 5 | 16809300 | This hypothesis was tested in alpha-1,3-galactosyltransferase knockout mice, which produce anti-Gal. |
| 6 | 17372027 | Efficacy of this treatment was demonstrated in alpha1,3-galactosyltransferase knockout mice producing anti-Gal and bearing B16 melanoma or B16/OVA producing OVA as a surrogate tumor Ag. |
| 7 | 18528300 | The alpha(1,3)galactosyltransferase (alphaGT) knockout mice (H-2) with preexisting subcutaneous and pulmonary tumors [alphaGal B16, H-2] received therapeutic vaccinations with S91M3alphaGal (H-2) whole cell allogeneic vaccines. |
| 8 | 21259410 | The Tn antigen is normally modified by a specific galactosyltransferase (T-synthase) in the Golgi apparatus of cells. |
| 9 | 21259410 | Expression of active T-synthase is uniquely dependent on the molecular chaperone Cosmc, which is encoded by a gene on the X chromosome. |
| 10 | 21259410 | Expression of the Tn antigen can arise as a consequence of mutations in the genes for T-synthase or Cosmc, or genes affecting other steps of O-glycosylation pathways. |
| 11 | 23023583 | To examine the immunogenicity of authentic cancer derived MUC1 glyco-epitopes, we expressed membrane bound forms of MUC1 tandem repeats in Jurkat, a mutant cancer cell line deficient of mucin-type core-1 β1-3 galactosyltransferase activity, and immunized mice with cancer cells expressing authentic MUC1 glyco-epitopes. |
| 12 | 23475714 | The presence of short N-glycan structures is explained by the low level of N-acetylglucosaminyltransferase I (GNT-I) activity and the absence of several other glycosyltransferases, such as GNT-II and β1,4-galactosyltransferase I (β1,4GalTI), and of sialyltransferases.In this chapter, we show that the glycosylation pathway of a lepidopteran cell line can be modified via infection with an engineered baculovirus to "humanize" the glycosylation pattern of a recombinant protein. |
| 13 | 23475714 | This engineering has been performed by introducing in the baculovirus genome the cDNAs that encode three mammalian glycosyltransferases (GNT-I, GNT-II, and β1,4GalTI). |
| 14 | 23577774 | This barrier has been overcome in the recent decade with the generation of α1,3-galactosyltransferase gene-knockout pigs. |
| 15 | 25354268 | The vaccine elicited strong antibody production against multiple TAAs in pancreatic cancer cells and induced activation of multiple tumor-specific T cells in α1,3-galactosyltransferase (α1,3GT) knockout (KO) mice. |
| 16 | 25354268 | The tumor lysate vaccine exhibited a similar effect on pancreatic cancer stem cells (CSCs) with the CD44+CD24+ phenotype. |
| 17 | 26384953 | To this end, the Galα(1,3)Galβ(1,4)GlcNAcα-BSA NGP was then used to immunize α1,3-galactosyltransferase-knockout mice, which produced antibody titers 40-fold higher as compared with pre-immunization titers. |